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10.1002/ddr.21732 http://scihub22266oqcxt.onion/10.1002/ddr.21732 32761647!7436322!32761647     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Dev+Res 2021 ; 82 (1): 38-48 Nephropedia Template TP {{tp|p=32761647|t=2021. Snake venom-derived bradykinin-potentiating peptides: A promising therapy for COVID-19?|pdf=|usr=}}{{32761647}} gab.com Text Snake venom-derived bradykinin-potentiating peptides: A promising therapy for COVID-19 JO: Drug Dev Res http://www.kidney.de/pget.php?&tw=1&pmid=32761647 #FOAvip The severe acute respiratory syndrome coronavirus-2 (SARS-COV-2), a novel coronavirus responsible for the recent infectious pandemic, is known to downregulate angiotensin-converting enzyme-2 (ACE2). Most current investigations focused on SARS-COV-2-related effects on the renin-angiotensin system and especially the resultant increase in angiotensin II, neglecting its effects on the kinin-kallikrein system. SARS-COV-2-induced ACE2 inhibition leads to the augmentation of bradykinin 1-receptor effects, as ACE2 inactivates des-Arg9-bradykinin, a bradykinin metabolite. SARS-COV-2 also decreases bradykinin 2-receptor effects as it affects bradykinin synthesis by inhibiting cathepsin L, a kininogenase present at the site of infection and involved in bradykinin production. The physiologies of both the renin-angiotensin and kinin-kallikrein system are functionally related suggesting that any intervention aiming to treat SARS-COV-2-infected patients by triggering one system but ignoring the other may not be adequately effective. Interestingly, the snake-derived bradykinin-potentiating peptide (BPP-10c) acts on both systems. BPP-10c strongly decreases angiotensin II by inhibiting ACE, increasing bradykinin-related effects on the bradykinin 2-receptor and increasing nitric oxide-mediated effects. Based on a narrative review of the literature, we suggest that BPP-10c could be an optimally effective option to consider when aiming at developing an anti-SARS-COV-2 drug. Twit Text FOAVip Snake venom-derived bradykinin-potentiating peptides: A promising therapy for COVID-19 ????Drug Dev Res http://www.kidney.de/pget.php?&tw=1&pmid=32761647 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32761647 #FOAvip English Wikipedia <ref>{{Cite pmid|32761647}}</ref> Snake venom-derived bradykinin-potentiating peptides: A promising therapy for COVID-19? #MMPMID32761647 Gouda AS; Megarbane B Drug Dev Res 2021[Feb]; 82 (1): 38-48 PMID32761647show ga The severe acute respiratory syndrome coronavirus-2 (SARS-COV-2), a novel coronavirus responsible for the recent infectious pandemic, is known to downregulate angiotensin-converting enzyme-2 (ACE2). Most current investigations focused on SARS-COV-2-related effects on the renin-angiotensin system and especially the resultant increase in angiotensin II, neglecting its effects on the kinin-kallikrein system. SARS-COV-2-induced ACE2 inhibition leads to the augmentation of bradykinin 1-receptor effects, as ACE2 inactivates des-Arg9-bradykinin, a bradykinin metabolite. SARS-COV-2 also decreases bradykinin 2-receptor effects as it affects bradykinin synthesis by inhibiting cathepsin L, a kininogenase present at the site of infection and involved in bradykinin production. The physiologies of both the renin-angiotensin and kinin-kallikrein system are functionally related suggesting that any intervention aiming to treat SARS-COV-2-infected patients by triggering one system but ignoring the other may not be adequately effective. Interestingly, the snake-derived bradykinin-potentiating peptide (BPP-10c) acts on both systems. BPP-10c strongly decreases angiotensin II by inhibiting ACE, increasing bradykinin-related effects on the bradykinin 2-receptor and increasing nitric oxide-mediated effects. Based on a narrative review of the literature, we suggest that BPP-10c could be an optimally effective option to consider when aiming at developing an anti-SARS-COV-2 drug. |*COVID-19 Drug Treatment[MESH] |Angiotensin-Converting Enzyme 2/antagonists & inhibitors/metabolism[MESH] |Animals[MESH] |Bradykinin/*administration & dosage/metabolism[MESH] |COVID-19/metabolism[MESH] |Humans[MESH] |Peptide Fragments/*administration & dosage/metabolism[MESH] |Renin-Angiotensin System/drug effects/physiology[MESH]Snake venom-derived bradykinin-potentiating peptides: A promising ther(epmc).pdf DeepDyve Pubget Overpricing