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10.3389/fimmu.2020.01782 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01782 32760409!7372085!32760409     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 1782 Nephropedia Template TP {{tp|p=32760409|t=2020. Could the Induction of Trained Immunity by beta-Glucan Serve as a Defense Against COVID-19?|pdf=|usr=}}{{32760409}} gab.com Text Could the Induction of Trained Immunity by beta-Glucan Serve as a Defense Against COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32760409 #FOAvip As the SARS-CoV-2 virus wreaks havoc on the populations, health care infrastructures and economies of nations around the world, finding ways to protect health care workers and bolster immune responses in the general population while we await an effective vaccine will be the difference between life and death for many people. Recent studies show that innate immune populations may possess a form of memory, termed Trained Immunity (TRIM), where innate immune cells undergo metabolic, mitochondrial, and epigenetic reprogramming following exposure to an initial stimulus that results in a memory phenotype of enhanced immune responses when exposed to a secondary, heterologous, stimulus. Throughout the literature, it has been shown that the induction of TRIM using such inducers as the BCG vaccine and beta-glucan can provide protection through altered immune responses against a range of viral infections. Here we hypothesize a potential role for beta-glucan in decreasing worldwide morbidity and mortality due to COVID-19, and posit several ideas as to how TRIM may actually shape the observed epidemiological phenomena related to COVID-19. We also evaluate the potential effects of beta-glucan in relation to the immune dysregulation and cytokine storm observed in COVID-19. Ultimately, we hypothesize that the use of oral beta-glucan in a prophylactic setting could be an effective way to boost immune responses and abrogate symptoms in COVID-19, though clinical trials are necessary to confirm the efficacy of this treatment and to further examine differential effects of beta-glucan's from various sources. Twit Text FOAVip Could the Induction of Trained Immunity by beta-Glucan Serve as a Defense Against COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32760409 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32760409 #FOAvip English Wikipedia <ref>{{Cite pmid|32760409}}</ref> Could the Induction of Trained Immunity by beta-Glucan Serve as a Defense Against COVID-19? #MMPMID32760409 Geller A; Yan J Front Immunol 2020[]; 11 (ä): 1782 PMID32760409show ga As the SARS-CoV-2 virus wreaks havoc on the populations, health care infrastructures and economies of nations around the world, finding ways to protect health care workers and bolster immune responses in the general population while we await an effective vaccine will be the difference between life and death for many people. Recent studies show that innate immune populations may possess a form of memory, termed Trained Immunity (TRIM), where innate immune cells undergo metabolic, mitochondrial, and epigenetic reprogramming following exposure to an initial stimulus that results in a memory phenotype of enhanced immune responses when exposed to a secondary, heterologous, stimulus. Throughout the literature, it has been shown that the induction of TRIM using such inducers as the BCG vaccine and beta-glucan can provide protection through altered immune responses against a range of viral infections. Here we hypothesize a potential role for beta-glucan in decreasing worldwide morbidity and mortality due to COVID-19, and posit several ideas as to how TRIM may actually shape the observed epidemiological phenomena related to COVID-19. We also evaluate the potential effects of beta-glucan in relation to the immune dysregulation and cytokine storm observed in COVID-19. Ultimately, we hypothesize that the use of oral beta-glucan in a prophylactic setting could be an effective way to boost immune responses and abrogate symptoms in COVID-19, though clinical trials are necessary to confirm the efficacy of this treatment and to further examine differential effects of beta-glucan's from various sources. |*Betacoronavirus[MESH] |Administration, Oral[MESH] |Adult[MESH] |Age Factors[MESH] |Animals[MESH] |Antiviral Agents/administration & dosage/immunology/pharmacology/*therapeutic use[MESH] |BCG Vaccine/immunology[MESH] |COVID-19[MESH] |Child[MESH] |Coronavirus Infections/blood/*diet therapy/*immunology/virology[MESH] |Cytokines/blood[MESH] |Dietary Fiber/administration & dosage/*therapeutic use[MESH] |Epigenesis, Genetic/immunology[MESH] |Humans[MESH] |Immunity, Innate/drug effects[MESH] |Immunologic Memory/*drug effects[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*diet therapy/*immunology/virology[MESH] |Pre-Exposure Prophylaxis[MESH] |SARS-CoV-2[MESH]Could the Induction of Trained Immunity by beta-Glucan Serve as a Defe(epmc).pdf DeepDyve Pubget Overpricing