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10.1038/s41435-020-0107-7 http://scihub22266oqcxt.onion/10.1038/s41435-020-0107-7 32759995!7484169!32759995     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+Immun 2020 ; 21 (4): 269-272 Nephropedia Template TP {{tp|p=32759995|t=2020. Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populations |pdf=|usr=}}{{32759995}} gab.com Text Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populations JO: Genes Immun http://www.kidney.de/pget.php?&tw=1&pmid=32759995 #FOAvip The entry of SARS-CoV-2 into host cells is dependent upon angiotensin-converting enzyme 2 (ACE2), which serves as a functional attachment receptor for the viral spike glycoprotein, and the serine protease TMPRSS2 which allows fusion of the viral and host cell membranes. We devised a quantitative measure to estimate genetic determinants of ACE2 and TMPRSS2 expression and applied this measure to >2500 individuals. Our data show significant variability in genetic determinants of ACE2 and TMPRSS2 expression among individuals and between populations, and indicate a genetic predisposition for lower expression levels of both key viral entry genes in African populations. These data suggest that host genetics related to viral entry mechanisms might influence interindividual variability in disease susceptibility and severity of COVID-19. Twit Text FOAVip Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populations ????Genes Immun http://www.kidney.de/pget.php?&tw=1&pmid=32759995 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32759995 #FOAvip English Wikipedia <ref>{{Cite pmid|32759995}}</ref> Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populations #MMPMID32759995 Ortiz-Fernandez L; Sawalha AH Genes Immun 2020[Aug]; 21 (4): 269-272 PMID32759995show ga The entry of SARS-CoV-2 into host cells is dependent upon angiotensin-converting enzyme 2 (ACE2), which serves as a functional attachment receptor for the viral spike glycoprotein, and the serine protease TMPRSS2 which allows fusion of the viral and host cell membranes. We devised a quantitative measure to estimate genetic determinants of ACE2 and TMPRSS2 expression and applied this measure to >2500 individuals. Our data show significant variability in genetic determinants of ACE2 and TMPRSS2 expression among individuals and between populations, and indicate a genetic predisposition for lower expression levels of both key viral entry genes in African populations. These data suggest that host genetics related to viral entry mechanisms might influence interindividual variability in disease susceptibility and severity of COVID-19. |Angiotensin-Converting Enzyme 2[MESH] |COVID-19[MESH] |Coronavirus Infections/ethnology/*genetics[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*genetics/metabolism[MESH] |Pneumonia, Viral/ethnology/*genetics[MESH] |Racial Groups/genetics[MESH]Genetic variability in the expression of the SARS-CoV-2 host cell entr(epmc).pdf DeepDyve Pubget Overpricing