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10.1016/j.mehy.2020.110148 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110148 32759016!7390780!32759016     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Hypotheses 2020 ; 143 (ä): 110148 Nephropedia Template TP {{tp|p=32759016|t=2020. Estrogen shields women from COVID-19 complications by reducing ER stress |pdf=|usr=}}{{32759016}} gab.com Text Estrogen shields women from COVID-19 complications by reducing ER stress JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32759016 #FOAvip Estrogen hormone acts as a potential key player in providing immunity against certain viral infection. It is found to be associated in providing immunity against acute lungs inflammation and influenza virus by modulating cytokines storm and mediating adaptive immune alterations respectively. Women are less affected by SARS-CoV-2 infection because of the possible influence of estrogen hormone as compared to men. We hypothesized that SARS-CoV-2 causes stress in endoplasmic reticulum (ER) which in turn aggravates the infection, estrogen hormone might play key role in decreasing ER stress by activating estrogen mediated signaling pathways, results in unfolded protein response (UPR). Estrogen governs degradation of phosphotidylinositol 4,5-bisphosphate (PIP(2)) into diacylglycerol (DAG) and inositol triphosphate (IP(3)) with the help of phospholipase C. IP(3) start in-fluxing Ca(+2) ions that helps in UPR activation. To support our hypothesis, we analyzed the data of 162,392 COVID-19 patients to determine the relation of this disease with gender. We observed that 26% of women and 74% of men were affected by SARS-CoV-2. It indicated that women are less affected because of the possible influence of estrogen hormone in women. Twit Text FOAVip Estrogen shields women from COVID-19 complications by reducing ER stress ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32759016 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32759016 #FOAvip English Wikipedia <ref>{{Cite pmid|32759016}}</ref> Estrogen shields women from COVID-19 complications by reducing ER stress #MMPMID32759016 Shabbir S; Hafeez A; Rafiq MA; Khan MJ Med Hypotheses 2020[Oct]; 143 (ä): 110148 PMID32759016show ga Estrogen hormone acts as a potential key player in providing immunity against certain viral infection. It is found to be associated in providing immunity against acute lungs inflammation and influenza virus by modulating cytokines storm and mediating adaptive immune alterations respectively. Women are less affected by SARS-CoV-2 infection because of the possible influence of estrogen hormone as compared to men. We hypothesized that SARS-CoV-2 causes stress in endoplasmic reticulum (ER) which in turn aggravates the infection, estrogen hormone might play key role in decreasing ER stress by activating estrogen mediated signaling pathways, results in unfolded protein response (UPR). Estrogen governs degradation of phosphotidylinositol 4,5-bisphosphate (PIP(2)) into diacylglycerol (DAG) and inositol triphosphate (IP(3)) with the help of phospholipase C. IP(3) start in-fluxing Ca(+2) ions that helps in UPR activation. To support our hypothesis, we analyzed the data of 162,392 COVID-19 patients to determine the relation of this disease with gender. We observed that 26% of women and 74% of men were affected by SARS-CoV-2. It indicated that women are less affected because of the possible influence of estrogen hormone in women. |*Betacoronavirus[MESH] |*Models, Biological[MESH] |*Pandemics[MESH] |Adult[MESH] |COVID-19[MESH] |Coronavirus Infections/epidemiology/metabolism/*physiopathology[MESH] |Datasets as Topic/statistics & numerical data[MESH] |Diglycerides/metabolism[MESH] |Disease Resistance[MESH] |Endoplasmic Reticulum Stress/*physiology[MESH] |Estrogens/*physiology[MESH] |Female[MESH] |Humans[MESH] |Inositol 1,4,5-Trisphosphate/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Pakistan/epidemiology[MESH] |Phosphatidylinositol 4,5-Diphosphate/metabolism[MESH] |Pneumonia, Viral/epidemiology/metabolism/*physiopathology[MESH] |SARS-CoV-2[MESH] |Sex Characteristics[MESH] |Sex Distribution[MESH] |Signal Transduction[MESH] |Type C Phospholipases/metabolism[MESH] |Unfolded Protein Response[MESH]Estrogen shields women from COVID-19 complications by reducing ER stre(epmc).pdf DeepDyve Pubget Overpricing