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10.1016/j.mehy.2020.110128 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110128 32758903!7373006!32758903     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Hypotheses 2020 ; 144 (ä): 110128 Nephropedia Template TP {{tp|p=32758903|t=2020. Mevalonate pathway, selenoproteins, redox balance, immune system, Covid-19: Reasoning about connections |pdf=|usr=}}{{32758903}} gab.com Text Mevalonate pathway, selenoproteins, redox balance, immune system, Covid-19: Reasoning about connections JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32758903 #FOAvip It has been proposed that a degraded immune system is (one of) the condition(s) that predispose certain subjects to fatal consequences from infection by SARS-CoV-2. It is unknown whether therapeutic regimens to which these patients may have been subjected to in the months/years preceding the infection could be immunocompromising. Statins are among the most widely prescribed cholesterol-lowering drugs. As competitive inhibitors of HMG-CoA-reductase, the key enzyme of the "mevalonate pathway" through which essential compounds, not only cholesterol, are synthesized, statins decrease the levels of cholesterol, and thus LDLs, as an innate defense mechanism, with controversial results in decreasing mortality from cardiovascular disease. Moreover, statins have pleiotropic, mostly deleterious effects on many cell types, including immune cells. In the attempt to decipher the enigma of SARS-CoV-2 infectivology, the hypothesis should be tested whether the population of subjects who succumbed to Covid-19 may have developed a compromised immunity at sub-clinical levels and have become more susceptible to fatal consequences from SARS-Cov-2 infection due to statin therapy. Twit Text FOAVip Mevalonate pathway, selenoproteins, redox balance, immune system, Covid-19: Reasoning about connections ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32758903 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32758903 #FOAvip English Wikipedia <ref>{{Cite pmid|32758903}}</ref> Mevalonate pathway, selenoproteins, redox balance, immune system, Covid-19: Reasoning about connections #MMPMID32758903 Minetti G Med Hypotheses 2020[Nov]; 144 (ä): 110128 PMID32758903show ga It has been proposed that a degraded immune system is (one of) the condition(s) that predispose certain subjects to fatal consequences from infection by SARS-CoV-2. It is unknown whether therapeutic regimens to which these patients may have been subjected to in the months/years preceding the infection could be immunocompromising. Statins are among the most widely prescribed cholesterol-lowering drugs. As competitive inhibitors of HMG-CoA-reductase, the key enzyme of the "mevalonate pathway" through which essential compounds, not only cholesterol, are synthesized, statins decrease the levels of cholesterol, and thus LDLs, as an innate defense mechanism, with controversial results in decreasing mortality from cardiovascular disease. Moreover, statins have pleiotropic, mostly deleterious effects on many cell types, including immune cells. In the attempt to decipher the enigma of SARS-CoV-2 infectivology, the hypothesis should be tested whether the population of subjects who succumbed to Covid-19 may have developed a compromised immunity at sub-clinical levels and have become more susceptible to fatal consequences from SARS-Cov-2 infection due to statin therapy. |*COVID-19 Drug Treatment[MESH] |*Oxidation-Reduction[MESH] |COVID-19/*immunology[MESH] |Cholesterol, LDL/metabolism[MESH] |Cholesterol/metabolism[MESH] |Enzyme Inhibitors/pharmacology[MESH] |Humans[MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology[MESH] |Immune System[MESH] |Immunity, Innate[MESH] |Inflammation[MESH] |Lipoproteins, LDL/metabolism[MESH] |Mevalonic Acid/*chemistry[MESH] |Models, Theoretical[MESH] |Oxidative Stress[MESH]Mevalonate pathway, selenoproteins, redox balance, immune system, Covi(epmc).pdf DeepDyve Pubget Overpricing