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10.1016/j.ijid.2020.06.079

http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.06.079
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suck abstract from ncbi


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pmid32758688      Int+J+Infect+Dis 2020 ; 99 (ä): 92-99
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  • The characteristics and predictive role of lymphocyte subsets in COVID-19 patients #MMPMID32758688
  • Zhang W; Li L; Liu J; Chen L; Zhou F; Jin T; Jiang L; Li X; Yang M; Wang H
  • Int J Infect Dis 2020[Oct]; 99 (ä): 92-99 PMID32758688show ga
  • OBJECTIVE: To investigate the characteristics and predictive roles of lymphocyte subsets in COVID-19 patients. METHOD: We evaluated lymphocyte subsets and other clinical features of COVID-19 patients, and analyzed their potential impacts on COVID-19 outcomes. RESULTS: 1. Lymphocyte subset counts in the peripheral blood of patients with COVID-19 were significantly reduced, especially in patients with severe disease. 2. In patients with non-severe disease, the time from symptom onset to hospital admission was positively correlated with total T cell counts. 3. Among COVID-19 patients who did not reach the composite endpoint, lymphocyte subset counts were higher than in patients who had reached the composite endpoint. 4. The Kaplan-Meier survival curves showed significant differences in COVID-19 patients, classified by the levels of total, CD8(+), and CD4(+) T cells at admission. CONCLUSION: Our study showed that total, CD8(+), and CD4(+) T cell counts in patients with COVID-19 were significantly reduced, especially in patients with severe disease. Lower T lymphocyte subsets were significantly associated with a higher occurrence of composite endpoint events. These subsets may help identify patients with a high risk of composite endpoint events.
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lymphocyte Count[MESH]
  • |Lymphocyte Subsets/*physiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*immunology[MESH]


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