The characteristics and predictive role of lymphocyte subsets in COVID-19 patients #MMPMID32758688
Zhang W; Li L; Liu J; Chen L; Zhou F; Jin T; Jiang L; Li X; Yang M; Wang H
Int J Infect Dis 2020[Oct]; 99 (?): 92-99 PMID32758688show ga
OBJECTIVE: To investigate the characteristics and predictive roles of lymphocyte subsets in COVID-19 patients. METHOD: We evaluated lymphocyte subsets and other clinical features of COVID-19 patients, and analyzed their potential impacts on COVID-19 outcomes. RESULTS: 1. Lymphocyte subset counts in the peripheral blood of patients with COVID-19 were significantly reduced, especially in patients with severe disease. 2. In patients with non-severe disease, the time from symptom onset to hospital admission was positively correlated with total T cell counts. 3. Among COVID-19 patients who did not reach the composite endpoint, lymphocyte subset counts were higher than in patients who had reached the composite endpoint. 4. The Kaplan-Meier survival curves showed significant differences in COVID-19 patients, classified by the levels of total, CD8(+), and CD4(+) T cells at admission. CONCLUSION: Our study showed that total, CD8(+), and CD4(+) T cell counts in patients with COVID-19 were significantly reduced, especially in patients with severe disease. Lower T lymphocyte subsets were significantly associated with a higher occurrence of composite endpoint events. These subsets may help identify patients with a high risk of composite endpoint events.
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Int+J+Infect+Dis 2020 ; 99 (?): 92-99
