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10.1177/0145561320940119

http://scihub22266oqcxt.onion/10.1177/0145561320940119
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32757995!7412078!32757995
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suck abstract from ncbi


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pmid32757995      Ear+Nose+Throat+J 2020 ; 99 (9): 94-98
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  • Acute Olfactory Dysfunction-A Primary Presentation of COVID-19 Infection #MMPMID32757995
  • Brookes NRG; Fairley JW; Brookes GB
  • Ear Nose Throat J 2020[Nov]; 99 (9): 94-98 PMID32757995show ga
  • COVID-19 is a zoonotic illness caused by a new strain of coronavirus and has recently been declared a pandemic by the World Health Organization, with an estimated fatality rate of 1% to 2%. Early identification and isolation of patients in the preliminary infective stage has been a mainstay of most governmental strategies in order to limit transmission. Four otherwise healthy patients presented to a specialist open access Ear, Nose & Throat Clinic in central London with acute total or subtotal loss of their sense of smell in a single one-week period, coinciding with rapid escalation of COVID-19 infection in the indigenous population. The diagnosis was confirmed by the validated University of Pennsylvania Smell Identification Test (UPSIT) in 3. Endoscopic examination and magnetic resonance imaging (2 cases) excluded a range of alternative potential pathological conditions. Covid-19 antibody testing carried out 6 to 8 weeks after the onset of nasal symptoms showed positive immunoglobulin G antibodies in 3 of the 4 patients. Acute severe anosmia is therefore almost certainly an unusual presenting local nasal feature of a COVID-19 viral infection. All 4 patients achieved significant partial olfactory recovery by one week after treatment with subjective ratings of 40% to 85% of normal (mean 60%) and complete olfaction recovery after 2 to 3 weeks in all 4 patients. The significance, possible pathogenesis, and public health implications are highlighted and discussed.
  • |Acute Disease[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coronavirus Infections/complications/*diagnosis[MESH]
  • |Female[MESH]
  • |Glucocorticoids/therapeutic use[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G[MESH]
  • |Male[MESH]
  • |Olfaction Disorders/*diagnosis/drug therapy/etiology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/*diagnosis[MESH]
  • |Recovery of Function[MESH]


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