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10.1111/tbed.13773

http://scihub22266oqcxt.onion/10.1111/tbed.13773
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32757470!7436438!32757470
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suck abstract from ncbi


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pmid32757470      Transbound+Emerg+Dis 2021 ; 68 (3): 1026-1032
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  • ACE2 isoform diversity predicts the host susceptibility of SARS-CoV-2 #MMPMID32757470
  • Gao S; Luan J; Cui H; Zhang L
  • Transbound Emerg Dis 2021[May]; 68 (3): 1026-1032 PMID32757470show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19) pandemic. Angiotensin-converting enzyme 2 (ACE2) is the functional receptor for SARS-CoV-2. In our current study, we found that two types of deficient ACE2 isoforms from different mammals compete with full-length ACE2 for association with S protein. One type of ACE2 is a natural soluble isoform, the other type of ACE2 only associates with one loop of the receptor-binding domain (RBD) of the SARS-CoV-2 S protein. Mammals with either type of ACE2 will be deficient in support of SARS-CoV-2 entry. By combining S recognition and isoform analysis of ACE2, we predict that felids, mustelids, hamsters, and sheep are susceptible to SARS-CoV-2, while canids, swines, cattle, and goats are not permissive for SARS-CoV-2. Thus, the differential susceptibilities of mammals with SARS-CoV-2 infection could be partially explained by the ACE2 isoform diversity. Our findings will shed important light on predicting the host range of other zoonotic viruses.
  • |*Genetic Predisposition to Disease[MESH]
  • |Angiotensin-Converting Enzyme 2/genetics/*metabolism[MESH]
  • |Animals[MESH]
  • |Gene Expression Regulation, Enzymologic[MESH]
  • |Humans[MESH]
  • |Isoenzymes[MESH]
  • |Mammals/*genetics[MESH]
  • |Protein Binding[MESH]
  • |SARS-CoV-2/*physiology[MESH]
  • |Species Specificity[MESH]


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