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10.1111/aji.13317

http://scihub22266oqcxt.onion/10.1111/aji.13317
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32757366!7435498!32757366
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suck abstract from ncbi


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pmid32757366      Am+J+Reprod+Immunol 2020 ; 84 (5): e13317
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  • Is pregnancy an immunological contributor to severe or controlled COVID-19 disease? #MMPMID32757366
  • Hanna N; Hanna M; Sharma S
  • Am J Reprod Immunol 2020[Nov]; 84 (5): e13317 PMID32757366show ga
  • Since its emergence in Wuhan as a novel coronavirus disease, it has taken only a few months since January 2020 for it to be recognized as a widespread COVID-19 pandemic which has contributed to global health devastation. As pointed out by health experts, it is a once in a century pandemic of our times. Clinical observations so far indicate that the older population and immune compromised individuals, particularly in African American and Hispanic/Latino communities, are at much higher risk for infection with this novel coronavirus. In this regard, pregnancy offers an altered immunity scenario which may allow severe COVID-19 disease. The literature is so far highly conflicting on this issue. This review will offer a conceptual basis for severe or controlled disease and address trepidations for pregnant women associated with COVID-19 pandemic, particularly in the comparative context of clinical consequences of other coronaviruses such as SARS and MERS. We will highlight the possible consequences of COVID-19 on the general health of pregnant women as well as its possible effects at the maternal-fetal interface. For the placenta-related pathology, we will focus our discussion on the temporal expression of ACE2 throughout gestation for possible propagation of SARS-CoV-2 in the placenta in infected women and ensuing consequences.
  • |Angiotensin-Converting Enzyme 2/metabolism[MESH]
  • |COVID-19/*immunology/virology[MESH]
  • |Disease Progression[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infectious Disease Transmission, Vertical[MESH]
  • |Maternal-Fetal Exchange[MESH]
  • |Pregnancy[MESH]
  • |Pregnancy Complications, Infectious/*immunology/virology[MESH]
  • |Pregnancy Outcome[MESH]
  • |SARS-CoV-2/*physiology[MESH]


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