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10.1371/journal.pone.0236754 http://scihub22266oqcxt.onion/10.1371/journal.pone.0236754 32756590!7406051!32756590     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2020 ; 15 (8): e0236754 Nephropedia Template TP {{tp|p=32756590|t=2020. Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats |pdf=|usr=}}{{32756590}} gab.com Text Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=32756590 #FOAvip The antimalarial agent mefloquine is currently being investigated for its potential to inhibit feline coronavirus and feline calicivirus infections. A simple, high pressure liquid chromatography assay was developed to detect mefloquine plasma concentrations in feline plasma. The assay's lower limit of quantification was 250 ng/mL. The mean +/- standard deviation intra- and inter-day precision expressed as coefficients of variation were 6.83 +/- 1.75 and 5.33 +/- 1.37%, respectively, whereas intra- and inter-day accuracy expressed as a percentage of the bias were 11.40 +/- 3.73 and 10.59 +/- 3.88%, respectively. Accordingly, this validated assay should prove valuable for future in vivo clinical trials of mefloquine as an antiviral agent against feline coronavirus and feline calicivirus. However, the proportion of mefloquine binding to feline plasma proteins has not been reported. The proportion of drug bound to plasma protein binding is an important concept when developing drug dosing regimens. As cats with feline infectious peritonitis (FIP) demonstrate altered concentrations of plasma proteins, the proportion of mefloquine binding to plasma proteins in both clinically normal cats and FIP-affected cats was also investigated. An in vitro method using rapid equilibrium dialysis demonstrated that mefloquine was highly plasma protein bound in both populations (on average > 99%). Twit Text FOAVip Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=32756590 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32756590 #FOAvip English Wikipedia <ref>{{Cite pmid|32756590}}</ref> Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats #MMPMID32756590 Izes AM; Kimble B; Norris JM; Govendir M PLoS One 2020[]; 15 (8): e0236754 PMID32756590show ga The antimalarial agent mefloquine is currently being investigated for its potential to inhibit feline coronavirus and feline calicivirus infections. A simple, high pressure liquid chromatography assay was developed to detect mefloquine plasma concentrations in feline plasma. The assay's lower limit of quantification was 250 ng/mL. The mean +/- standard deviation intra- and inter-day precision expressed as coefficients of variation were 6.83 +/- 1.75 and 5.33 +/- 1.37%, respectively, whereas intra- and inter-day accuracy expressed as a percentage of the bias were 11.40 +/- 3.73 and 10.59 +/- 3.88%, respectively. Accordingly, this validated assay should prove valuable for future in vivo clinical trials of mefloquine as an antiviral agent against feline coronavirus and feline calicivirus. However, the proportion of mefloquine binding to feline plasma proteins has not been reported. The proportion of drug bound to plasma protein binding is an important concept when developing drug dosing regimens. As cats with feline infectious peritonitis (FIP) demonstrate altered concentrations of plasma proteins, the proportion of mefloquine binding to plasma proteins in both clinically normal cats and FIP-affected cats was also investigated. An in vitro method using rapid equilibrium dialysis demonstrated that mefloquine was highly plasma protein bound in both populations (on average > 99%). |Animals[MESH] |Blood Proteins/genetics[MESH] |Caliciviridae Infections/drug therapy/veterinary/virology[MESH] |Calicivirus, Feline/*drug effects/pathogenicity[MESH] |Cats[MESH] |Coronavirus, Feline/*drug effects/pathogenicity[MESH] |Feline Infectious Peritonitis/blood/*drug therapy/virology[MESH] |Mefloquine/*pharmacology[MESH]Assay validation and determination of in vitro binding of mefloquine t(epmc).pdf DeepDyve Pubget Overpricing