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10.3390/ijms21155559 http://scihub22266oqcxt.onion/10.3390/ijms21155559 32756480!7432271!32756480     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (15): ä Nephropedia Template TP {{tp|p=32756480|t=2020. COVID-19: The Immune Responses and Clinical Therapy Candidates |pdf=|usr=}}{{32756480}} gab.com Text COVID-19: The Immune Responses and Clinical Therapy Candidates JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32756480 #FOAvip The pandemic of coronavirus disease 2019 (COVID-19), with rising numbers of patients worldwide, presents an urgent need for effective treatments. To date, there are no therapies or vaccines that are proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several potential candidates or repurposed drugs are under investigation, including drugs that inhibit SARS-CoV-2 replication and block infection. The most promising therapy to date is remdesivir, which is US Food and Drug Administration (FDA) approved for emergency use in adults and children hospitalized with severe suspected or laboratory-confirmed COVID-19. Herein we summarize the general features of SARS-CoV-2's molecular and immune pathogenesis and discuss available pharmacological strategies, based on our present understanding of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) infections. Finally, we outline clinical trials currently in progress to investigate the efficacy of potential therapies for COVID-19. Twit Text FOAVip COVID-19: The Immune Responses and Clinical Therapy Candidates ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32756480 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32756480 #FOAvip English Wikipedia <ref>{{Cite pmid|32756480}}</ref> COVID-19: The Immune Responses and Clinical Therapy Candidates #MMPMID32756480 Zhand S; Saghaeian Jazi M; Mohammadi S; Tarighati Rasekhi R; Rostamian G; Kalani MR; Rostamian A; George J; Douglas MW Int J Mol Sci 2020[Aug]; 21 (15): ä PMID32756480show ga The pandemic of coronavirus disease 2019 (COVID-19), with rising numbers of patients worldwide, presents an urgent need for effective treatments. To date, there are no therapies or vaccines that are proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several potential candidates or repurposed drugs are under investigation, including drugs that inhibit SARS-CoV-2 replication and block infection. The most promising therapy to date is remdesivir, which is US Food and Drug Administration (FDA) approved for emergency use in adults and children hospitalized with severe suspected or laboratory-confirmed COVID-19. Herein we summarize the general features of SARS-CoV-2's molecular and immune pathogenesis and discuss available pharmacological strategies, based on our present understanding of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) infections. Finally, we outline clinical trials currently in progress to investigate the efficacy of potential therapies for COVID-19. |*Adaptive Immunity[MESH] |Anti-Inflammatory Agents/therapeutic use[MESH] |Antiviral Agents/therapeutic use[MESH] |Betacoronavirus/isolation & purification/*physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/immunology/*pathology/therapy/virology[MESH] |Humans[MESH] |Immunotherapy[MESH] |Middle East Respiratory Syndrome Coronavirus/isolation & purification/physiology[MESH] |Open Reading Frames/genetics[MESH] |Pandemics[MESH] |Pneumonia, Viral/immunology/*pathology/therapy/virology[MESH]COVID-19: The Immune Responses and Clinical Therapy Candidates (epmc).pdf DeepDyve Pubget Overpricing