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10.3390/ijerph17155589

http://scihub22266oqcxt.onion/10.3390/ijerph17155589
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32756371!7432030!32756371
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suck abstract from ncbi


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pmid32756371      Int+J+Environ+Res+Public+Health 2020 ; 17 (15): ä
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  • BCG Vaccination and Mortality of COVID-19 across 173 Countries: An Ecological Study #MMPMID32756371
  • Urashima M; Otani K; Hasegawa Y; Akutsu T
  • Int J Environ Res Public Health 2020[Aug]; 17 (15): ä PMID32756371show ga
  • Ecological studies have suggested fewer COVID-19 morbidities and mortalities in Bacillus Calmette-Guerin (BCG)-vaccinated countries than BCG-non-vaccinated countries. However, these studies obtained data during the early phase of the pandemic and did not adjust for potential confounders, including PCR-test numbers per population (PCR-tests). Currently-more than four months after declaration of the pandemic-the BCG-hypothesis needs reexamining. An ecological study was conducted by obtaining data of 61 factors in 173 countries, including BCG vaccine coverage (%), using morbidity and mortality as outcomes, obtained from open resources. 'Urban population (%)' and 'insufficient physical activity (%)' in each country was positively associated with morbidity, but not mortality, after adjustment for PCR-tests. On the other hand, recent BCG vaccine coverage (%) was negatively associated with mortality, but not morbidity, even with adjustment for percentage of the population >/= 60 years of age, morbidity, PCR-tests and other factors. The results of this study generated a hypothesis that a national BCG vaccination program seems to be associated with reduced mortality of COVID-19, although this needs to be further examined and proved by randomized clinical trials.
  • |BCG Vaccine/*administration & dosage[MESH]
  • |Betacoronavirus/*isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*mortality/virology[MESH]
  • |Humans[MESH]
  • |Middle Aged[MESH]
  • |Pandemics/prevention & control[MESH]
  • |Pneumonia, Viral/*mortality/virology[MESH]
  • |Research Design[MESH]
  • |SARS-CoV-2[MESH]


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