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10.1097/MD.0000000000021513 http://scihub22266oqcxt.onion/10.1097/MD.0000000000021513 32756189!7402888!32756189     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Medicine+(Baltimore) 2020 ; 99 (31): e21513 Nephropedia Template TP {{tp|p=32756189|t=2020. D-dimer surge and coagulation disorders in COVID-19 related pneumonia patients with cardiac injury: A case series |pdf=|usr=}}{{32756189}} gab.com Text D-dimer surge and coagulation disorders in COVID-19 related pneumonia patients with cardiac injury: A case series JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=32756189 #FOAvip BACKGROUND: Cardiac injury and coagulation disorders have been two increasing concerns in the management of patients with severe coronavirus disease (COVID-19). Coagulation disorders in COVID-19 patients with cardiac injury have not been characterized. METHODS: We analyzed the data of five COVID-19 patients with cardiac injury who had D-dimer surge (defined as a rapid increase in the D-dimer level in 72 h, from <5-21 mug/mL) during hospitalization, which were extracted from a registered retrospective study (ChiCTR2000031301). Clinical data and data on changes in coagulation parameters were collected, verified, and characterized. RESULTS: Among these five patients, four had pre-existing cardiovascular or cerebrovascular diseases. D-dimer surge was accompanied with prolonged prothrombin time (PT) and reduced platelet count (PLT) and fibrinogen level. Three patients had an ISTH DIC score of 5 and met the criteria for overt DIC. All five patients needed invasive ventilation support and were incubated 0 to 6 days after the first D-dimer upper reference limit (URL) was reached. All five patients died within 10 days after the first D-dimer URL was reached. All five patients had observed D-dimer URL results 1 to 3 days before death. CONCLUSION: D-dimer surge in COVID-19 patients with cardiac injury surely leads to worse in-hospital outcome. D-dimer surge and concomitant DIC can be the leading causes of in-hospital death. Pre-existing cardiovascular or cerebrovascular diseases might pose a higher risk for developing these coagulation disorders. These findings can serve as hypothesis generating and need further clinical trials to confirm. Twit Text FOAVip D-dimer surge and coagulation disorders in COVID-19 related pneumonia patients with cardiac injury: A case series ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=32756189 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32756189 #FOAvip English Wikipedia <ref>{{Cite pmid|32756189}}</ref> D-dimer surge and coagulation disorders in COVID-19 related pneumonia patients with cardiac injury: A case series #MMPMID32756189 Wang X; Du B; Li J; Wang S; Wang X; Guo M; Yang B; Si D; Bai O Medicine (Baltimore) 2020[Jul]; 99 (31): e21513 PMID32756189show ga BACKGROUND: Cardiac injury and coagulation disorders have been two increasing concerns in the management of patients with severe coronavirus disease (COVID-19). Coagulation disorders in COVID-19 patients with cardiac injury have not been characterized. METHODS: We analyzed the data of five COVID-19 patients with cardiac injury who had D-dimer surge (defined as a rapid increase in the D-dimer level in 72 h, from <5-21 mug/mL) during hospitalization, which were extracted from a registered retrospective study (ChiCTR2000031301). Clinical data and data on changes in coagulation parameters were collected, verified, and characterized. RESULTS: Among these five patients, four had pre-existing cardiovascular or cerebrovascular diseases. D-dimer surge was accompanied with prolonged prothrombin time (PT) and reduced platelet count (PLT) and fibrinogen level. Three patients had an ISTH DIC score of 5 and met the criteria for overt DIC. All five patients needed invasive ventilation support and were incubated 0 to 6 days after the first D-dimer upper reference limit (URL) was reached. All five patients died within 10 days after the first D-dimer URL was reached. All five patients had observed D-dimer URL results 1 to 3 days before death. CONCLUSION: D-dimer surge in COVID-19 patients with cardiac injury surely leads to worse in-hospital outcome. D-dimer surge and concomitant DIC can be the leading causes of in-hospital death. Pre-existing cardiovascular or cerebrovascular diseases might pose a higher risk for developing these coagulation disorders. These findings can serve as hypothesis generating and need further clinical trials to confirm. |*Betacoronavirus[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Blood Coagulation Disorders/*virology[MESH] |COVID-19[MESH] |Cardiovascular Diseases/*virology[MESH] |Coronavirus Infections/*blood/complications/virology[MESH] |Fatal Outcome[MESH] |Fibrin Fibrinogen Degradation Products/*metabolism[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*blood/complications/virology[MESH] |Retrospective Studies[MESH]D-dimer surge and coagulation disorders in COVID-19 related pneumonia (epmc).pdf DeepDyve Pubget Overpricing