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MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19 #MMPMID32755992
Bilezikian JP; Bikle D; Hewison M; Lazaretti-Castro M; Formenti AM; Gupta A; Madhavan MV; Nair N; Babalyan V; Hutchings N; Napoli N; Accili D; Binkley N; Landry DW; Giustina A
Eur J Endocrinol 2020[Nov]; 183 (5): R133-R147 PMID32755992show ga
The SARS-CoV-2 virus responsible for the COVID-19 pandemic has generated an explosion of interest both in the mechanisms of infection leading to dissemination and expression of this disease, and in potential risk factors that may have a mechanistic basis for disease propagation or control. Vitamin D has emerged as a factor that may be involved in these two areas. The focus of this article is to apply our current understanding of vitamin D as a facilitator of immunocompetence both with regard to innate and adaptive immunity and to consider how this may relate to COVID-19 disease. There are also intriguing potential links to vitamin D as a factor in the cytokine storm that portends some of the most serious consequences of SARS-CoV-2 infection, such as the acute respiratory distress syndrome. Moreover, cardiac and coagulopathic features of COVID-19 disease deserve attention as they may also be related to vitamin D. Finally, we review the current clinical data associating vitamin D with SARS-CoV-2 infection, a putative clinical link that at this time must still be considered hypothetical.
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Eur+J+Endocrinol 2020 ; 183 (5): R133-R147
