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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Diabetes+Metab+Syndr 2020 ; 14 (5): 1431-1437 Nephropedia Template TP
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Impact of COVID -19 in cancer patients on severity of disease and fatal outcomes: A systematic review and meta-analysis #MMPMID32755847
Salunke AA; Nandy K; Pathak SK; Shah J; Kamani M; Kottakota V; Thivari P; Pandey A; Patel K; Rathod P; Bhatt S; Dave P; Pandya S
Diabetes Metab Syndr 2020[Sep]; 14 (5): 1431-1437 PMID32755847show ga
BACKGROUND AND AIMSBACKGROUND: Currently there is limited knowledge on cancer and COVID-19; we conducted a systematic review and meta-analysis to evaluate the impact of cancer on serious events including ICU admission rate and mortality in COVID 19. METHODS: PubMed, Cochrane Central Register of Clinical Trials were searched on April 16, 2020, to extract published articles that reported the outcomes of cancer in COVID-19 patients. The search terms were "coronavirus" and "clinical characteristics" with no language or time restrictions. We identified 512 published results and 13 studies were included in the analysis. RESULTS: There were 3775 patients, of whom 63 (1.66%) had a cancer. The pooled estimates of ICU admission in COVID 19 patients with and without cancer were 40% versus 8.42%.The odds ratio of ICU admission rates between the cancer and non-cancer groups was 2.88 with a 95% CI of 1.18 to 7.01 (p = 0.026). The pooled estimates of death rate in COVID -19 patients with and without cancer were 20.83% versus 7.82%. The odds ratio of death rates between the cancer and non-cancer groups was 2.25 with a 95% CI ranging from 0.71 to 7.10 with p value of 0.166. The pooled prevalence of cancer patients was 2% (95 CI 1-4). CONCLUSIONS: Presence of cancer in COVID-19 leads to higher risk of developing serious events i.e. ICU admission, mechanical ventilation and mortality. The presence of cancer has a significant impact on mortality rate in COVID-19 patients.