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10.1016/j.ijantimicag.2020.106129 http://scihub22266oqcxt.onion/10.1016/j.ijantimicag.2020.106129 32755653!7396133!32755653     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Antimicrob+Agents 2020 ; 56 (4): 106129 Nephropedia Template TP {{tp|p=32755653|t=2020. Impact of medical care, including use of anti-infective agents, on prognosis of COVID-19 hospitalized patients over time |pdf=|usr=}}{{32755653}} gab.com Text Impact of medical care, including use of anti-infective agents, on prognosis of COVID-19 hospitalized patients over time JO: Int J Antimicrob Agents http://www.kidney.de/pget.php?&tw=1&pmid=32755653 #FOAvip INTRODUCTION: The effect of anti-infective agents in COVID-19 is unclear. The impact of changes in practice on prognosis over time has not been evaluated. METHODS: Single center, retrospective study in adults hospitalized in a medicine ward for COVID-19 from March 5(th) to April 25(th) 2020. Patient characteristics were compared between two periods (before/after March 19(th)) considering French guidelines. The aim of the study was to evaluate how medical care impacted unfavorable outcome, namely admission to intensive care unit (ICU) and/or death. RESULTS: A total of 132 patients were admitted: mean age 59.0+/-16.3 years; mean C-reactive protein (CRP) level 84.0+/-71.1 mg/L; 46% had a lymphocyte count <1000/mm(3). Prescribed anti-infective agents were lopinavir-ritonavir (n=12), azithromycin (AZI) (n=28) and AZI combined with hydroxychloroquine (HCQ) (n=52). There was a significant decrease in ICU admission, from 43% to 12%, between the two periods (P<0.0001). Delays until transfer to ICU were similar between periods (P=0.86). Pulmonary computerized tomography (CT)-scans were performed significantly more often with time (from 50% to 90%, P<0.0001), and oxygen-dependency (53% vs 80%, P=0.001) and prescription of AZI+/-HCQ (from 25% to 76%, P<0.0001) were also greater over time. Multivariate analyses showed a reduction of unfavorable outcome in patients receiving AZI+/-HCQ (hazard ratio [HR]=0.45, 95% confidence interval [CI: 0.21-0.97], P=0.04), particularly among an identified category of individuals (lymphocyte >/=1000/mm(3) or CRP >/=100 mg/L). CONCLUSION: The present study showed a significant decrease in admission to ICU over time, which was probably related to multiple factors, including a better indication of pulmonary CT-scan, oxygen therapy, and a suitable prescription of anti-infective agents. Twit Text FOAVip Impact of medical care, including use of anti-infective agents, on prognosis of COVID-19 hospitalized patients over time ????Int J Antimicrob Agents http://www.kidney.de/pget.php?&tw=1&pmid=32755653 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32755653 #FOAvip English Wikipedia <ref>{{Cite pmid|32755653}}</ref> Impact of medical care, including use of anti-infective agents, on prognosis of COVID-19 hospitalized patients over time #MMPMID32755653 Davido B; Boussaid G; Vaugier I; Lansaman T; Bouchand F; Lawrence C; Alvarez JC; Moine P; Perronne V; Barbot F; Saleh-Mghir A; Perronne C; Annane D; De Truchis P Int J Antimicrob Agents 2020[Oct]; 56 (4): 106129 PMID32755653show ga INTRODUCTION: The effect of anti-infective agents in COVID-19 is unclear. The impact of changes in practice on prognosis over time has not been evaluated. METHODS: Single center, retrospective study in adults hospitalized in a medicine ward for COVID-19 from March 5(th) to April 25(th) 2020. Patient characteristics were compared between two periods (before/after March 19(th)) considering French guidelines. The aim of the study was to evaluate how medical care impacted unfavorable outcome, namely admission to intensive care unit (ICU) and/or death. RESULTS: A total of 132 patients were admitted: mean age 59.0+/-16.3 years; mean C-reactive protein (CRP) level 84.0+/-71.1 mg/L; 46% had a lymphocyte count <1000/mm(3). Prescribed anti-infective agents were lopinavir-ritonavir (n=12), azithromycin (AZI) (n=28) and AZI combined with hydroxychloroquine (HCQ) (n=52). There was a significant decrease in ICU admission, from 43% to 12%, between the two periods (P<0.0001). Delays until transfer to ICU were similar between periods (P=0.86). Pulmonary computerized tomography (CT)-scans were performed significantly more often with time (from 50% to 90%, P<0.0001), and oxygen-dependency (53% vs 80%, P=0.001) and prescription of AZI+/-HCQ (from 25% to 76%, P<0.0001) were also greater over time. Multivariate analyses showed a reduction of unfavorable outcome in patients receiving AZI+/-HCQ (hazard ratio [HR]=0.45, 95% confidence interval [CI: 0.21-0.97], P=0.04), particularly among an identified category of individuals (lymphocyte >/=1000/mm(3) or CRP >/=100 mg/L). CONCLUSION: The present study showed a significant decrease in admission to ICU over time, which was probably related to multiple factors, including a better indication of pulmonary CT-scan, oxygen therapy, and a suitable prescription of anti-infective agents. |Adult[MESH] |Aged[MESH] |Anti-Infective Agents/*therapeutic use[MESH] |Azithromycin/*therapeutic use[MESH] |Betacoronavirus/*drug effects/pathogenicity[MESH] |C-Reactive Protein/metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/diagnostic imaging/*drug therapy/mortality/pathology[MESH] |Disease Progression[MESH] |Drug Combinations[MESH] |Female[MESH] |Humans[MESH] |Hydroxychloroquine/*therapeutic use[MESH] |Intensive Care Units[MESH] |Lopinavir/*therapeutic use[MESH] |Male[MESH] |Middle Aged[MESH] |Multivariate Analysis[MESH] |Pandemics[MESH] |Pneumonia, Viral/diagnostic imaging/*drug therapy/mortality/pathology[MESH] |Prognosis[MESH] |Retrospective Studies[MESH] |Ritonavir/*therapeutic use[MESH] |SARS-CoV-2[MESH] |Survival Analysis[MESH] |T-Lymphocytes/pathology/virology[MESH] |Tomography, X-Ray Computed[MESH]Impact of medical care, including use of anti-infective agents, on pro(epmc).pdf DeepDyve Pubget Overpricing