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10.1016/j.celrep.2020.108016 http://scihub22266oqcxt.onion/10.1016/j.celrep.2020.108016 32755598!7380208!32755598     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2020 ; 32 (6): 108016 Nephropedia Template TP {{tp|p=32755598|t=2020. A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2 |pdf=|usr=}}{{32755598}} gab.com Text A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2 JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=32755598 #FOAvip The influenza virus hemagglutinin (HA) and coronavirus spike (S) protein mediate virus entry. HA and S proteins are heavily glycosylated, making them potential targets for carbohydrate binding agents such as lectins. Here, we show that the lectin FRIL, isolated from hyacinth beans (Lablab purpureus), has anti-influenza and anti-SARS-CoV-2 activity. FRIL can neutralize 11 representative human and avian influenza strains at low nanomolar concentrations, and intranasal administration of FRIL is protective against lethal H1N1 infection in mice. FRIL binds preferentially to complex-type N-glycans and neutralizes viruses that possess complex-type N-glycans on their envelopes. As a homotetramer, FRIL is capable of aggregating influenza particles through multivalent binding and trapping influenza virions in cytoplasmic late endosomes, preventing their nuclear entry. Remarkably, FRIL also effectively neutralizes SARS-CoV-2, preventing viral protein production and cytopathic effect in host cells. These findings suggest a potential application of FRIL for the prevention and/or treatment of influenza and COVID-19. Twit Text FOAVip A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2 ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=32755598 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32755598 #FOAvip English Wikipedia <ref>{{Cite pmid|32755598}}</ref> A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2 #MMPMID32755598 Liu YM; Shahed-Al-Mahmud M; Chen X; Chen TH; Liao KS; Lo JM; Wu YM; Ho MC; Wu CY; Wong CH; Jan JT; Ma C Cell Rep 2020[Aug]; 32 (6): 108016 PMID32755598show ga The influenza virus hemagglutinin (HA) and coronavirus spike (S) protein mediate virus entry. HA and S proteins are heavily glycosylated, making them potential targets for carbohydrate binding agents such as lectins. Here, we show that the lectin FRIL, isolated from hyacinth beans (Lablab purpureus), has anti-influenza and anti-SARS-CoV-2 activity. FRIL can neutralize 11 representative human and avian influenza strains at low nanomolar concentrations, and intranasal administration of FRIL is protective against lethal H1N1 infection in mice. FRIL binds preferentially to complex-type N-glycans and neutralizes viruses that possess complex-type N-glycans on their envelopes. As a homotetramer, FRIL is capable of aggregating influenza particles through multivalent binding and trapping influenza virions in cytoplasmic late endosomes, preventing their nuclear entry. Remarkably, FRIL also effectively neutralizes SARS-CoV-2, preventing viral protein production and cytopathic effect in host cells. These findings suggest a potential application of FRIL for the prevention and/or treatment of influenza and COVID-19. |A549 Cells[MESH] |Administration, Intranasal[MESH] |Animals[MESH] |Antiviral Agents/administration & dosage/pharmacology/*therapeutic use[MESH] |Betacoronavirus/drug effects[MESH] |COVID-19[MESH] |Chick Embryo[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/*drug therapy[MESH] |Dogs[MESH] |Fabaceae/*chemistry[MESH] |Female[MESH] |Humans[MESH] |Influenza A Virus, H1N1 Subtype/drug effects[MESH] |Madin Darby Canine Kidney Cells[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Orthomyxoviridae Infections/*drug therapy[MESH] |Pandemics[MESH] |Plant Lectins/administration & dosage/pharmacology/*therapeutic use[MESH] |Pneumonia, Viral/*drug therapy[MESH] |Protein Binding[MESH] |SARS-CoV-2[MESH] |Vero Cells[MESH]A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectivel(epmc).pdf DeepDyve Pubget Overpricing