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10.1080/07853890.2020.1802061

http://scihub22266oqcxt.onion/10.1080/07853890.2020.1802061
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32755287!7877997!32755287
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suck abstract from ncbi


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pmid32755287      Ann+Med 2020 ; 52 (7): 334-344
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  • Characterisation of clinical, laboratory and imaging factors related to mild vs severe covid-19 infection: a systematic review and meta-analysis #MMPMID32755287
  • Wu X; Liu L; Jiao J; Yang L; Zhu B; Li X
  • Ann Med 2020[Nov]; 52 (7): 334-344 PMID32755287show ga
  • BACKGROUND: Early detection of disease progression associated with severe COVID-19, and access to proper medical care lowers fatality rates of severe cases. Currently, no studies had systematically examined the variables in detecting severe COVID-19. METHOD: Systematic searching of electronic databases identified observational studies which recruited participants with confirmed COVID-19 infection who were divided into different groups according to disease severity were identified. RESULTS: To analysis 41 studies with 5064 patients were included.Patients who are elderly (SMD, 1.90; 95% CI, 1.01 to 2.8), male (OR, 1.71; 95% CI, 1.39 to 2.11) and have comorbidities or flu-like symptoms were significantly associated with the development to severe cases. Severe cases were associated with significant increased WBC (OR, 5.83; 95% CI, 2.76 to 12.32), CRP (OR, 3.62; 95% CI, 1.62 to 8.03), D-dimer (SMD, 1.69; 95% CI, 1.09 to 2.28), AST (OR, 4.64; 95% CI, 3.18 to 6.77) and LDH (OR, 7.94; 95% CI, 2.09 to 30.21). CT manifestation of bilateral lung involvement (OR, 4.55; 95% CI, 2.17 to 9.51) was associated with the severe cases. Conclusions and Relevance: Our findings offer guidance for a wide spectrum of clinicians to early identify severe COVID-19 patients, transport to specialised centres, and initiate appropriate treatment. Key Messages This systematic review and meta-analysis examined 41 studies including 5,064 patients with confirmed COVID-19. Severe cases were associated with age, male gender, and with fever, cough and respiratory diseases, increased WBC, CRP, D-dimer, AST and LDH levels. Furthermore, CT manifestation of bilateral lung involvement was associated with the severe cases. These findings provide guidance to health professionals with early identification of severe COVID-19 patients, transportation to specialised care and initiate appropriate supportive treatment.
  • |*Tomography, X-Ray Computed[MESH]
  • |Age Factors[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/diagnostic imaging/*epidemiology/physiopathology[MESH]
  • |Disease Progression[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lung/*diagnostic imaging[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnostic imaging/*epidemiology/physiopathology[MESH]
  • |Risk Factors[MESH]


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