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10.1007/s00405-020-06267-2

http://scihub22266oqcxt.onion/10.1007/s00405-020-06267-2
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32754871!7402072!32754871
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suck abstract from ncbi


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pmid32754871      Eur+Arch+Otorhinolaryngol 2021 ; 278 (1): 101-108
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  • Psychophysical evaluation of chemosensory functions 5 weeks after olfactory loss due to COVID-19: a prospective cohort study on 72 patients #MMPMID32754871
  • Le Bon SD; Pisarski N; Verbeke J; Prunier L; Cavelier G; Thill MP; Rodriguez A; Dequanter D; Lechien JR; Le Bon O; Hummel T; Horoi M
  • Eur Arch Otorhinolaryngol 2021[Jan]; 278 (1): 101-108 PMID32754871show ga
  • PURPOSE: To evaluate the evolution of chemosensation via extended psychophysical testing in patients who suffered from sudden chemosensory loss due to coronavirus disease 2019 (COVID-19). Additionally, this study sought to determine whether odor threshold testing provided additional information on olfactory loss due to COVID-19 compared to the more common odor identification testing. METHODS: Prospective cohort study of patients with sudden chemosensory loss since February 2020 and confirmed COVID-19 infection via RT-PCR or serology testing. Olfactory function was tested extensively using the "Sniffin Sticks" test battery. In addition, we screened gustatory perception and nasal cooling sensations using psychophysical tests. RESULTS: Seventy-two patients completed the study. After a mean of 37 days, 37% of patients showed olfactory dysfunction, 7% were dysgeusic, and 48% showed signs of low sensitivity for cooling sensation. A longer duration of anosmia before smell improvement was correlated with lower olfactory function at 5 weeks. Odor threshold detection was more affected by COVID-19 compared to odor identification. CONCLUSION: Five weeks after developing sudden chemosensory loss due to COVID-19, a high proportion of patients were dysosmic and showed signs of low nasal cooling sensitivity, whereas most of them had normal taste function. SARS-CoV-2 affected mainly odor thresholds, possibly suggesting that the major cause of loss of smell lies at the level of the olfactory neuroepithelium, rather than in the central nervous system.
  • |Adult[MESH]
  • |Anosmia/*etiology/psychology[MESH]
  • |COVID-19/complications/*diagnosis/epidemiology/*psychology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Odorants[MESH]
  • |Olfaction Disorders/*etiology[MESH]
  • |Prospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Smell/*physiology[MESH]


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