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10.3389/fendo.2020.00525

http://scihub22266oqcxt.onion/10.3389/fendo.2020.00525
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32754119!7365851!32754119
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suck abstract from ncbi


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pmid32754119      Front+Endocrinol+(Lausanne) 2020 ; 11 (ä): 525
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  • Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019 #MMPMID32754119
  • Zhang J; Kong W; Xia P; Xu Y; Li L; Li Q; Yang L; Wei Q; Wang H; Li H; Zheng J; Sun H; Xia W; Liu G; Zhong X; Qiu K; Li Y; Wang H; Wang Y; Song X; Liu H; Xiong S; Liu Y; Cui Z; Hu Y; Chen L; Pan A; Zeng T
  • Front Endocrinol (Lausanne) 2020[]; 11 (ä): 525 PMID32754119show ga
  • Background: Diabetes correlates with poor prognosis in patients with COVID-19, but very few studies have evaluated whether impaired fasting glucose (IFG) is also a risk factor for the poor outcomes of patients with COVID-19. Here we aimed to examine the associations between IFG and diabetes at admission with risks of complications and mortality among patients with COVID-19. Methods: In this multicenter retrospective cohort study, we enrolled 312 hospitalized patients with COVID-19 from 5 hospitals in Wuhan from Jan 1 to Mar 17, 2020. Clinical information, laboratory findings, complications, treatment regimens, and mortality status were collected. The associations between hyperglycemia and diabetes status at admission with primary composite end-point events (including mechanical ventilation, admission to intensive care unit, or death) were analyzed by Cox proportional hazards regression models. Results: The median age of the patients was 57 years (interquartile range 38-66), and 172 (55%) were women. At the time of hospital admission, 84 (27%) had diabetes (and 36 were new-diagnosed), 62 (20%) had IFG, and 166 (53%) had normal fasting glucose (NFG) levels. Compared to patients with NFG, patients with IFG and diabetes developed more primary composite end-point events (9 [5%], 11 [18%], 26 [31%]), including receiving mechanical ventilation (5 [3%], 6 [10%], 21 [25%]), and death (4 [2%], 9 [15%], 20 [24%]). Multivariable Cox regression analyses showed diabetes was associated increased risks of primary composite end-point events (hazard ratio 3.53; 95% confidence interval 1.48-8.40) and mortality (6.25; 1.91-20.45), and IFG was associated with an increased risk of mortality (4.11; 1.15-14.74), after adjusting for age, sex, hospitals and comorbidities. Conclusion: IFG and diabetes at admission were associated with higher risks of adverse outcomes among patients with COVID-19.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Betacoronavirus/isolation & purification[MESH]
  • |Blood Glucose/*metabolism[MESH]
  • |COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Coronavirus Infections/complications/epidemiology/*mortality/virology[MESH]
  • |Diabetes Complications/epidemiology/*mortality/virology[MESH]
  • |Diabetes Mellitus/*physiopathology/virology[MESH]
  • |Fasting[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Glucose Intolerance/*complications/virology[MESH]
  • |Hospital Mortality[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Hyperglycemia/*complications/virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/epidemiology/*mortality/virology[MESH]
  • |Prognosis[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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