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10.3389/fneur.2020.00806

http://scihub22266oqcxt.onion/10.3389/fneur.2020.00806
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32754114!7365850!32754114
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suck abstract from ncbi


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pmid32754114      Front+Neurol 2020 ; 11 (ä): 806
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  • Neurological Manifestations in Critically Ill Patients With COVID-19: A Retrospective Study #MMPMID32754114
  • Fan S; Xiao M; Han F; Xia P; Bai X; Chen H; Zhang H; Ding X; Zhao H; Zhao J; Sun X; Jiang W; Wang C; Cao W; Guo F; Tian R; Gao P; Wu W; Ma J; Wu D; Liu Z; Zhou X; Wang J; Guan T; Qin Y; Li T; Xu Y; Zhang D; Chen Y; Xie J; Li Y; Yan X; Zhu Y; Peng B; Cui L; Zhang S; Guan H
  • Front Neurol 2020[]; 11 (ä): 806 PMID32754114show ga
  • Background: The complications of coronavirus disease 2019 (COVID-19) involved multiple organs or systems, especially in critically ill patients. We aim to investigate the neurological complications in critically ill patients with COVID-19. Methods: This retrospective single-center case series analyzed critically ill patients with COVID-19 at the intensive care unit of Tongji Hospital, Wuhan, China from February 5 to April 2, 2020. Demographic data, clinical and laboratory findings, comorbidities and treatments were collected and analyzed. Results: Among 86 patients with confirmed COVID-19, 54 patients (62.8%) were male, and the mean (SD) age was 66.6 (11.1) years. Overall, 65% patients presented with at least one neurological symptom. Twenty patients (23.3%) had symptoms involving the central nervous system, including delirium, cerebrovascular diseases and hypoxic-ischemic brain injury, while 6 patients (7%) had neuromuscular involvement. Seven of 86 patients exhibited new stroke and 6 (7%) cases were ischemic. A significantly higher prevalence of antiphospholipid antibodies was observed in patients with ischemic stroke than in those without stroke (83.3 vs. 26.9%, p < 0.05). Patients with ischemic stroke were more likely to have a higher myoglobulin level, and a lower hemoglobin level. Conclusions: The clinical spectrum of neurological complications in critically ill patients with COVID-19 was broad. Stroke, delirium and neuromuscular diseases are common neurological complications of COVID-19. Physicians should pay close attention to neurological complications in critically ill patients with COVID-19.
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