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10.1126/science.abd3871 http://scihub22266oqcxt.onion/10.1126/science.abd3871 32753554!7574914!32753554     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2020 ; 370 (6512): 89-94 Nephropedia Template TP {{tp|p=32753554|t=2020. Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans |pdf=|usr=}}{{32753554}} gab.com Text Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=32753554 #FOAvip Many unknowns exist about human immune responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2-reactive CD4(+) T cells have been reported in unexposed individuals, suggesting preexisting cross-reactive T cell memory in 20 to 50% of people. However, the source of those T cells has been speculative. Using human blood samples derived before the SARS-CoV-2 virus was discovered in 2019, we mapped 142 T cell epitopes across the SARS-CoV-2 genome to facilitate precise interrogation of the SARS-CoV-2-specific CD4(+) T cell repertoire. We demonstrate a range of preexisting memory CD4(+) T cells that are cross-reactive with comparable affinity to SARS-CoV-2 and the common cold coronaviruses human coronavirus (HCoV)-OC43, HCoV-229E, HCoV-NL63, and HCoV-HKU1. Thus, variegated T cell memory to coronaviruses that cause the common cold may underlie at least some of the extensive heterogeneity observed in coronavirus disease 2019 (COVID-19) disease. Twit Text FOAVip Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans ????Science http://www.kidney.de/pget.php?&tw=1&pmid=32753554 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32753554 #FOAvip English Wikipedia <ref>{{Cite pmid|32753554}}</ref> Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans #MMPMID32753554 Mateus J; Grifoni A; Tarke A; Sidney J; Ramirez SI; Dan JM; Burger ZC; Rawlings SA; Smith DM; Phillips E; Mallal S; Lammers M; Rubiro P; Quiambao L; Sutherland A; Yu ED; da Silva Antunes R; Greenbaum J; Frazier A; Markmann AJ; Premkumar L; de Silva A; Peters B; Crotty S; Sette A; Weiskopf D Science 2020[Oct]; 370 (6512): 89-94 PMID32753554show ga Many unknowns exist about human immune responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2-reactive CD4(+) T cells have been reported in unexposed individuals, suggesting preexisting cross-reactive T cell memory in 20 to 50% of people. However, the source of those T cells has been speculative. Using human blood samples derived before the SARS-CoV-2 virus was discovered in 2019, we mapped 142 T cell epitopes across the SARS-CoV-2 genome to facilitate precise interrogation of the SARS-CoV-2-specific CD4(+) T cell repertoire. We demonstrate a range of preexisting memory CD4(+) T cells that are cross-reactive with comparable affinity to SARS-CoV-2 and the common cold coronaviruses human coronavirus (HCoV)-OC43, HCoV-229E, HCoV-NL63, and HCoV-HKU1. Thus, variegated T cell memory to coronaviruses that cause the common cold may underlie at least some of the extensive heterogeneity observed in coronavirus disease 2019 (COVID-19) disease. |*Immunologic Memory[MESH] |Betacoronavirus/genetics/*immunology[MESH] |Blood Donors[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology[MESH] |Cross Reactions[MESH] |Epitope Mapping[MESH] |Epitopes, T-Lymphocyte/genetics/*immunology[MESH] |Genome, Viral[MESH] |Humans[MESH] |Open Reading Frames[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology[MESH] |SARS-CoV-2[MESH]Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed h(epmc).pdf DeepDyve Pubget Overpricing