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10.3390/diagnostics10080539 http://scihub22266oqcxt.onion/10.3390/diagnostics10080539 32751741!7459734!32751741     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diagnostics+(Basel) 2020 ; 10 (8): ä Nephropedia Template TP {{tp|p=32751741|t=2020. COVID-19-Related Coagulopathy-Is Transferrin a Missing Link?|pdf=|usr=}}{{32751741}} gab.com Text COVID-19-Related Coagulopathy-Is Transferrin a Missing Link JO: Diagnostics (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=32751741 #FOAvip SARS-CoV-2 is the causative agent of COVID-19. Severe COVID-19 disease has been associated with disseminated intravascular coagulation and thrombosis, but the mechanisms underlying COVID-19-related coagulopathy remain unknown. The risk of severe COVID-19 disease is higher in males than in females and increases with age. To identify gene products that may contribute to COVID-19-related coagulopathy, we analyzed the expression of genes associated with the Gene Ontology (GO) term "blood coagulation" in the Genotype-Tissue Expression (GTEx) database and identified four procoagulants, whose expression is higher in males and increases with age (ADAMTS13, F11, HGFAC, KLKB1), and two anticoagulants, whose expression is higher in females and decreases with age (C1QTNF1, SERPINA5). However, the expression of none of these genes was regulated in a proteomics dataset of SARS-CoV-2-infected cells and none of the proteins have been identified as a binding partner of SARS-CoV-2 proteins. Hence, they may rather generally predispose individuals to thrombosis without directly contributing to COVID-19-related coagulopathy. In contrast, the expression of the procoagulant transferrin (not associated to the GO term "blood coagulation") was higher in males, increased with age, and was upregulated upon SARS-CoV-2 infection. Hence, transferrin warrants further examination in ongoing clinic-pathological investigations. Twit Text FOAVip COVID-19-Related Coagulopathy-Is Transferrin a Missing Link ????Diagnostics (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=32751741 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32751741 #FOAvip English Wikipedia <ref>{{Cite pmid|32751741}}</ref> COVID-19-Related Coagulopathy-Is Transferrin a Missing Link? #MMPMID32751741 McLaughlin KM; Bechtel M; Bojkova D; Munch C; Ciesek S; Wass MN; Michaelis M; Cinatl J Jr Diagnostics (Basel) 2020[Jul]; 10 (8): ä PMID32751741show ga SARS-CoV-2 is the causative agent of COVID-19. Severe COVID-19 disease has been associated with disseminated intravascular coagulation and thrombosis, but the mechanisms underlying COVID-19-related coagulopathy remain unknown. The risk of severe COVID-19 disease is higher in males than in females and increases with age. To identify gene products that may contribute to COVID-19-related coagulopathy, we analyzed the expression of genes associated with the Gene Ontology (GO) term "blood coagulation" in the Genotype-Tissue Expression (GTEx) database and identified four procoagulants, whose expression is higher in males and increases with age (ADAMTS13, F11, HGFAC, KLKB1), and two anticoagulants, whose expression is higher in females and decreases with age (C1QTNF1, SERPINA5). However, the expression of none of these genes was regulated in a proteomics dataset of SARS-CoV-2-infected cells and none of the proteins have been identified as a binding partner of SARS-CoV-2 proteins. Hence, they may rather generally predispose individuals to thrombosis without directly contributing to COVID-19-related coagulopathy. In contrast, the expression of the procoagulant transferrin (not associated to the GO term "blood coagulation") was higher in males, increased with age, and was upregulated upon SARS-CoV-2 infection. Hence, transferrin warrants further examination in ongoing clinic-pathological investigations. äCOVID-19-Related Coagulopathy-Is Transferrin a Missing Link?(epmc).pdf DeepDyve Pubget Overpricing