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10.3390/ijms21155388

http://scihub22266oqcxt.onion/10.3390/ijms21155388
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32751307!7432834!32751307
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suck abstract from ncbi


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pmid32751307      Int+J+Mol+Sci 2020 ; 21 (15): ä
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  • Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism #MMPMID32751307
  • Lombardi G; Ziemann E; Banfi G; Corbetta S
  • Int J Mol Sci 2020[Jul]; 21 (15): ä PMID32751307show ga
  • Exercise perturbs homeostasis, alters the levels of circulating mediators and hormones, and increases the demand by skeletal muscles and other vital organs for energy substrates. Exercise also affects bone and mineral metabolism, particularly calcium and phosphate, both of which are essential for muscle contraction, neuromuscular signaling, biosynthesis of adenosine triphosphate (ATP), and other energy substrates. Parathyroid hormone (PTH) is involved in the regulation of calcium and phosphate homeostasis. Understanding the effects of exercise on PTH secretion is fundamental for appreciating how the body adapts to exercise. Altered PTH metabolism underlies hyperparathyroidism and hypoparathyroidism, the complications of which affect the organs involved in calcium and phosphorous metabolism (bone and kidney) and other body systems as well. Exercise affects PTH expression and secretion by altering the circulating levels of calcium and phosphate. In turn, PTH responds directly to exercise and exercise-induced myokines. Here, we review the main concepts of the regulation of PTH expression and secretion under physiological conditions, in acute and chronic exercise, and in relation to PTH-related disorders.
  • |*Exercise[MESH]
  • |Bone and Bones/cytology/metabolism[MESH]
  • |Calcium/*metabolism[MESH]
  • |Fibronectins/genetics/metabolism[MESH]
  • |Gene Expression Regulation[MESH]
  • |Homeostasis/genetics[MESH]
  • |Humans[MESH]
  • |Hyperparathyroidism/genetics/*metabolism/pathology[MESH]
  • |Hypoparathyroidism/genetics/*metabolism/pathology[MESH]
  • |Interleukins/genetics/metabolism[MESH]
  • |Kidney/cytology/metabolism[MESH]
  • |Metabolic Networks and Pathways/genetics[MESH]
  • |Muscle Contraction/genetics[MESH]
  • |Neuromuscular Junction/genetics/metabolism/pathology[MESH]
  • |Parathyroid Hormone/*genetics/metabolism[MESH]
  • |Phosphorus/*metabolism[MESH]
  • |Signal Transduction[MESH]


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