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10.1109/TCBB.2020.3009099 http://scihub22266oqcxt.onion/10.1109/TCBB.2020.3009099 32750889!ä!32750889 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32750889.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       IEEE/ACM+Trans+Comput+Biol+Bioinform 2021 ; 18 (4): 1230-1233 Nephropedia Template TP {{tp|p=32750889|t=2021. AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells |pdf=|usr=}}{{32750889}} gab.com Text AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells JO: IEEE/ACM Trans Comput Biol Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=32750889 #FOAvip Recently, it was confirmed that ACE2 is the receptor of SARS-CoV-2, the pathogen causing the recent outbreak of severe pneumonia around the world. It is confused that ACE2 is widely expressed across a variety of organs and is expressed moderately but not highly in lung, which, however, is the major infected organ. Therefore, we hypothesized that there could be some other genes playing key roles in the entry of SARS-CoV-2 into human cells. Here we found that AGTR2 (angiotensin II receptor type 2), a G-protein coupled receptor, has interaction with ACE2 and is highly expressed in lung with a high tissue specificity. More importantly, simulation of 3D structure based protein-protein interaction reveals that AGTR2 shows a higher binding affinity with the Spike protein of SARS-CoV-2 than ACE2 (energy: -8.2 vs. -5.1 [kcal/mol]). A number of compounds, biologics and traditional Chinese medicine that could decrease the expression level of AGTR2 were predicted. Finally, we suggest that AGTR2 could be a putative novel gene for the entry of SARS-CoV-2 into human cells, which could provide different insight for the research of SARS-CoV-2 proteins with their receptors. Twit Text FOAVip AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells ????IEEE/ACM Trans Comput Biol Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=32750889 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32750889 #FOAvip English Wikipedia <ref>{{Cite pmid|32750889}}</ref> AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells #MMPMID32750889 Cui C; Huang C; Zhou W; Ji X; Zhang F; Wang L; Zhou Y; Cui Q IEEE/ACM Trans Comput Biol Bioinform 2021[Jul]; 18 (4): 1230-1233 PMID32750889show ga Recently, it was confirmed that ACE2 is the receptor of SARS-CoV-2, the pathogen causing the recent outbreak of severe pneumonia around the world. It is confused that ACE2 is widely expressed across a variety of organs and is expressed moderately but not highly in lung, which, however, is the major infected organ. Therefore, we hypothesized that there could be some other genes playing key roles in the entry of SARS-CoV-2 into human cells. Here we found that AGTR2 (angiotensin II receptor type 2), a G-protein coupled receptor, has interaction with ACE2 and is highly expressed in lung with a high tissue specificity. More importantly, simulation of 3D structure based protein-protein interaction reveals that AGTR2 shows a higher binding affinity with the Spike protein of SARS-CoV-2 than ACE2 (energy: -8.2 vs. -5.1 [kcal/mol]). A number of compounds, biologics and traditional Chinese medicine that could decrease the expression level of AGTR2 were predicted. Finally, we suggest that AGTR2 could be a putative novel gene for the entry of SARS-CoV-2 into human cells, which could provide different insight for the research of SARS-CoV-2 proteins with their receptors. |*SARS-CoV-2/drug effects/pathogenicity/physiology[MESH] |Angiotensin-Converting Enzyme 2/chemistry/physiology[MESH] |Antiviral Agents/pharmacology[MESH] |COVID-19/*genetics/physiopathology/*virology[MESH] |Computational Biology[MESH] |Computer Simulation[MESH] |Drug Evaluation, Preclinical[MESH] |Humans[MESH] |Models, Molecular[MESH] |Protein Interaction Maps[MESH] |Receptor, Angiotensin, Type 2/chemistry/*genetics/physiology[MESH] |Receptors, Virus/chemistry/*genetics/physiology[MESH] |Serine Endopeptidases/genetics[MESH] |Spike Glycoprotein, Coronavirus/chemistry/physiology[MESH] |Transcriptome/drug effects[MESH]AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Hu(epmc).pdf DeepDyve Pubget Overpricing