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10.1109/TCBB.2020.3009099

http://scihub22266oqcxt.onion/10.1109/TCBB.2020.3009099
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32750889!ä!32750889

suck abstract from ncbi


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pmid32750889      IEEE/ACM+Trans+Comput+Biol+Bioinform 2021 ; 18 (4): 1230-1233
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  • AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells #MMPMID32750889
  • Cui C; Huang C; Zhou W; Ji X; Zhang F; Wang L; Zhou Y; Cui Q
  • IEEE/ACM Trans Comput Biol Bioinform 2021[Jul]; 18 (4): 1230-1233 PMID32750889show ga
  • Recently, it was confirmed that ACE2 is the receptor of SARS-CoV-2, the pathogen causing the recent outbreak of severe pneumonia around the world. It is confused that ACE2 is widely expressed across a variety of organs and is expressed moderately but not highly in lung, which, however, is the major infected organ. Therefore, we hypothesized that there could be some other genes playing key roles in the entry of SARS-CoV-2 into human cells. Here we found that AGTR2 (angiotensin II receptor type 2), a G-protein coupled receptor, has interaction with ACE2 and is highly expressed in lung with a high tissue specificity. More importantly, simulation of 3D structure based protein-protein interaction reveals that AGTR2 shows a higher binding affinity with the Spike protein of SARS-CoV-2 than ACE2 (energy: -8.2 vs. -5.1 [kcal/mol]). A number of compounds, biologics and traditional Chinese medicine that could decrease the expression level of AGTR2 were predicted. Finally, we suggest that AGTR2 could be a putative novel gene for the entry of SARS-CoV-2 into human cells, which could provide different insight for the research of SARS-CoV-2 proteins with their receptors.
  • |*SARS-CoV-2/drug effects/pathogenicity/physiology[MESH]
  • |Angiotensin-Converting Enzyme 2/chemistry/physiology[MESH]
  • |Antiviral Agents/pharmacology[MESH]
  • |COVID-19/*genetics/physiopathology/*virology[MESH]
  • |Computational Biology[MESH]
  • |Computer Simulation[MESH]
  • |Drug Evaluation, Preclinical[MESH]
  • |Humans[MESH]
  • |Models, Molecular[MESH]
  • |Protein Interaction Maps[MESH]
  • |Receptor, Angiotensin, Type 2/chemistry/*genetics/physiology[MESH]
  • |Receptors, Virus/chemistry/*genetics/physiology[MESH]
  • |Serine Endopeptidases/genetics[MESH]
  • |Spike Glycoprotein, Coronavirus/chemistry/physiology[MESH]
  • |Transcriptome/drug effects[MESH]


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  • suck abstract from ncbi

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