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10.1159/000509807 http://scihub22266oqcxt.onion/10.1159/000509807 32750694!7490487!32750694     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32750694&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nephron 2020 ; 144 (11): 550-554 Nephropedia Template TP {{tp|p=32750694|t=2020. Rationale for Medium Cutoff Membranes in COVID-19 Patients Requiring Renal Replacement Therapy |pdf=|usr=}}{{32750694}} gab.com Text Rationale for Medium Cutoff Membranes in COVID-19 Patients Requiring Renal Replacement Therapy JO: Nephron http://www.kidney.de/pget.php?&tw=1&pmid=32750694 #FOAvip The current pandemic of coronavirus disease 2019 (COVID-19) spotlighted the vulnerability of patients with chronic kidney disease stage 5 on maintenance hemodialysis (HD) to the viral infection. Social distancing is the most effective preventive measure to reduce the risk of infection. Nonetheless, the necessity to frequently reach the dialysis center and the inherent social gathering both impede social distancing and also self-quarantine for infected individuals. A baseline hyperinflammatory state driven by factors such as the retention of uremic toxins afflicts these patients. Concomitantly, a condition of relative immunosuppression is also attributed to similar factors. The use of high-flux (HF) dialyzers for HD is the standard of care. However, with HF membranes, the removal of large middle molecules is scant. Medium cutoff (MCO) dialyzers are a new class of membranes that allow substantial removal of large middle molecules with negligible albumin losses. Recent trials confirmed long-term safety and long-term sustained reduction in the concentration of large uremic toxins with MCO dialyzers. Herein, we discuss the rationale for applying MCO membranes in COVID-19 patients and its possible immunoadjuvant effects that could mitigate the burden of COVID-19 infection in dialysis patients. We also discuss the direct cytopathic effect of the virus on renal tissue and extracorporeal blood purification techniques that can prevent kidney damage or reduce acute kidney injury progression. Twit Text FOAVip Rationale for Medium Cutoff Membranes in COVID-19 Patients Requiring Renal Replacement Therapy ????Nephron http://www.kidney.de/pget.php?&tw=1&pmid=32750694 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32750694 #FOAvip English Wikipedia <ref>{{Cite pmid|32750694}}</ref> Rationale for Medium Cutoff Membranes in COVID-19 Patients Requiring Renal Replacement Therapy #MMPMID32750694 Ronco C; Reis T; Cozzolino M Nephron 2020[]; 144 (11): 550-554 PMID32750694show ga The current pandemic of coronavirus disease 2019 (COVID-19) spotlighted the vulnerability of patients with chronic kidney disease stage 5 on maintenance hemodialysis (HD) to the viral infection. Social distancing is the most effective preventive measure to reduce the risk of infection. Nonetheless, the necessity to frequently reach the dialysis center and the inherent social gathering both impede social distancing and also self-quarantine for infected individuals. A baseline hyperinflammatory state driven by factors such as the retention of uremic toxins afflicts these patients. Concomitantly, a condition of relative immunosuppression is also attributed to similar factors. The use of high-flux (HF) dialyzers for HD is the standard of care. However, with HF membranes, the removal of large middle molecules is scant. Medium cutoff (MCO) dialyzers are a new class of membranes that allow substantial removal of large middle molecules with negligible albumin losses. Recent trials confirmed long-term safety and long-term sustained reduction in the concentration of large uremic toxins with MCO dialyzers. Herein, we discuss the rationale for applying MCO membranes in COVID-19 patients and its possible immunoadjuvant effects that could mitigate the burden of COVID-19 infection in dialysis patients. We also discuss the direct cytopathic effect of the virus on renal tissue and extracorporeal blood purification techniques that can prevent kidney damage or reduce acute kidney injury progression. |*Membranes, Artificial[MESH] |*Renal Replacement Therapy[MESH] |Betacoronavirus/isolation & purification[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/epidemiology/virology[MESH] |Humans[MESH] |Kidney Failure, Chronic/complications/physiopathology/*therapy[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/epidemiology/virology[MESH]Rationale for Medium Cutoff Membranes in COVID-19 Patients Requiring R(epmc).pdf DeepDyve Pubget Overpricing