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10.1007/s00415-020-10123-y

http://scihub22266oqcxt.onion/10.1007/s00415-020-10123-y
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32749601!7400751!32749601
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suck abstract from ncbi

pmid32749601      J+Neurol 2021 ; 268 (3): 762-769
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  • Neurological comorbidity and severity of COVID-19 #MMPMID32749601
  • Romagnolo A; Balestrino R; Imbalzano G; Ciccone G; Riccardini F; Artusi CA; Bozzali M; Ferrero B; Montalenti E; Montanaro E; Rizzone MG; Vaula G; Zibetti M; Lopiano L
  • J Neurol 2021[Mar]; 268 (3): 762-769 PMID32749601show ga
  • OBJECTIVE: Neurological symptoms of COVID-19 patients have been recently described. However, no comprehensive data have been reported on pre-existing neurological comorbidities and COVID-19. This study aims at evaluating the prevalence of neurological comorbidities, and their association with COVID-19 severity. METHODS: We evaluated all consecutive patients admitted to the Emergency Room (ER) of our hospital between the 3rd March and the 14th April 2020, and diagnosed with COVID-19. Data on neurological and non-neurological diseases were extracted, as well as data on demographic characteristics and on severity degree of COVID-19. The prevalence of neurological comorbidities was calculated, and multivariate binary logistic regression analyses were used to estimate the association between neurological diseases and COVID-19 severity. RESULTS: We included 344 patients. Neurological comorbidities accounted for 22.4% of cases, with cerebrovascular diseases and cognitive impairment being the most frequent. Neurological comorbidity resulted independently associated with severe COVID-19 (OR 2.305; p = 0.012), as well as male gender (p = 0.001), older age (p = 0.001), neoplastic diseases (p = 0.039), and arterial hypertension (p = 0.045). When neurological comorbidity was associated with non-neurological comorbidities, the OR for severe COVID-19 rose to 7.394 (p = 0.005). Neurological patients, in particular cerebrovascular and cognitively impaired ones, received more respiratory support indication. CONCLUSION: Neurological comorbidities represent a significant determinant of COVID-19 severity, deserving a thorough evaluation since the earliest phases of infection. The vulnerability of patients affected by neurological diseases should suggest a greater attention in targeting this population for proactive viral screening.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*complications/*epidemiology[MESH]
  • |Cerebrovascular Disorders/epidemiology/etiology[MESH]
  • |Cognitive Dysfunction/epidemiology/etiology[MESH]
  • |Comorbidity[MESH]
  • |Emergency Medical Services/statistics & numerical data[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Hypertension/complications[MESH]
  • |Logistic Models[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Neoplasms/complications[MESH]
  • |Nervous System Diseases/*epidemiology/*etiology[MESH]
  • |Prevalence[MESH]
  • |Sex Factors[MESH]


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