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10.1002/ptr.6802 http://scihub22266oqcxt.onion/10.1002/ptr.6802 32748969!7436756!32748969     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Phytother+Res 2020 ; 34 (12): 3411-3419 Nephropedia Template TP {{tp|p=32748969|t=2020. Evaluation of medicinal herbs as a potential therapeutic option against SARS-CoV-2 targeting its main protease |pdf=|usr=}}{{32748969}} gab.com Text Evaluation of medicinal herbs as a potential therapeutic option against SARS-CoV-2 targeting its main protease JO: Phytother Res http://www.kidney.de/pget.php?&tw=1&pmid=32748969 #FOAvip The COVID-19 disease caused by the SARS-CoV-2 has emerged as a worldwide pandemic and caused huge damage to the lives and economy of more than hundred countries. As on May 10, 2020, more than 4,153,300 people stand infected from the virus due to an unprecedented rate of transmission and 282,700 have lost their lives because of the disease. In this context, medicinal plants may provide a way to treat the disease by targeting specific essential proteins of the virus. We screened about 51 medicinal plants and found that Tea (Camellia sinensis) and Haritaki (Terminalia chebula) has potential against SARS-COV-2 3CL(pro) , with an IC(50) for Green Tea as 8.9 +/- 0.5 mug/ml and Haritaki 8.8 +/- 0.5 mug/ml. The in-silico studies suggested that Tea component Thearubigins binds to the cysteine 145 of protease active site and could be a pharmacoactive molecule. We predict that the inhibition in protease activity may be able to halt the SARS-CoV-2 replication cycle and therefore, we propose Green Tea, Black Tea, and Haritaki plant extracts as potential therapeutic candidates for SARS-CoV-2 infection. Further investigation on role of bioactive constituents of extracts is needed to establish the molecular basis of inhibition and towards expedited drug discovery. Twit Text FOAVip Evaluation of medicinal herbs as a potential therapeutic option against SARS-CoV-2 targeting its main protease ????Phytother Res http://www.kidney.de/pget.php?&tw=1&pmid=32748969 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32748969 #FOAvip English Wikipedia <ref>{{Cite pmid|32748969}}</ref> Evaluation of medicinal herbs as a potential therapeutic option against SARS-CoV-2 targeting its main protease #MMPMID32748969 Upadhyay S; Tripathi PK; Singh M; Raghavendhar S; Bhardwaj M; Patel AK Phytother Res 2020[Dec]; 34 (12): 3411-3419 PMID32748969show ga The COVID-19 disease caused by the SARS-CoV-2 has emerged as a worldwide pandemic and caused huge damage to the lives and economy of more than hundred countries. As on May 10, 2020, more than 4,153,300 people stand infected from the virus due to an unprecedented rate of transmission and 282,700 have lost their lives because of the disease. In this context, medicinal plants may provide a way to treat the disease by targeting specific essential proteins of the virus. We screened about 51 medicinal plants and found that Tea (Camellia sinensis) and Haritaki (Terminalia chebula) has potential against SARS-COV-2 3CL(pro) , with an IC(50) for Green Tea as 8.9 +/- 0.5 mug/ml and Haritaki 8.8 +/- 0.5 mug/ml. The in-silico studies suggested that Tea component Thearubigins binds to the cysteine 145 of protease active site and could be a pharmacoactive molecule. We predict that the inhibition in protease activity may be able to halt the SARS-CoV-2 replication cycle and therefore, we propose Green Tea, Black Tea, and Haritaki plant extracts as potential therapeutic candidates for SARS-CoV-2 infection. Further investigation on role of bioactive constituents of extracts is needed to establish the molecular basis of inhibition and towards expedited drug discovery. |*Camellia sinensis[MESH] |*Terminalia[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |Computer Simulation[MESH] |Coronavirus 3C Proteases/*antagonists & inhibitors[MESH] |Drug Discovery[MESH] |Plants, Medicinal[MESH] |Protease Inhibitors/*pharmacology[MESH]Evaluation of medicinal herbs as a potential therapeutic option agains(epmc).pdf DeepDyve Pubget Overpricing