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10.1177/1074248420947628

http://scihub22266oqcxt.onion/10.1177/1074248420947628
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32748634!7404086!32748634
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suck abstract from ncbi


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pmid32748634      J+Cardiovasc+Pharmacol+Ther 2020 ; 25 (6): 503-507
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  • Renin-Angiotensin System Blockade and Mortality in Patients With Hypertension and COVID-19 Infection #MMPMID32748634
  • Salah HM; Calcaterra G; Mehta JL
  • J Cardiovasc Pharmacol Ther 2020[Nov]; 25 (6): 503-507 PMID32748634show ga
  • To determine the effect renin-angiotensin system blockers on the outcome in patients with hypertension and concurrent COVID-19 infection, we searched PubMed, the Cochrane Library, and Google Scholar for relevant articles. Twelve studies with a total of 16,101 patients met the inclusion criteria. The mortality rate among the users of angiotensin converting enzyme inhibitors or angiotensin receptor blockers was 12.15% and in non-users it was 14.56% (risk ratio 0.70, 95% CI [0.53-0.91], P < 0.007). There was no difference in the risk of death between the use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers (risk ratio 1.09, 95% CI [0.90 -1.32]). We conclude that the use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers improves mortality in patients with hypertension and concurrent COVID-19 infection, without a significant difference between ACEIs and ARBs in this population.
  • |Angiotensin II Type 1 Receptor Blockers[MESH]
  • |Angiotensin Receptor Antagonists/*therapeutic use[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors/*therapeutic use[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*epidemiology/mortality[MESH]
  • |Humans[MESH]
  • |Hypertension/*drug therapy/*epidemiology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*epidemiology/mortality[MESH]
  • |Renin-Angiotensin System/physiology[MESH]


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