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  • Histopathological findings in the advanced natural evolution of the SARS-CoV-2 infection #MMPMID32747912
  • Cirstea AE; Buzulica RL; Pirici D; Ceausu MC; Iman RV; Gheorghe OM; Neamtu SD; Stanca L; Ene R; Kumar-Singh S; Mogoanta L
  • Rom J Morphol Embryol 2020[]; 61 (1): 209-218 PMID32747912show ga
  • We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the Department of Forensic Medicine from Emergency County Hospital, Drobeta Turnu Severin, Mehedinti County, Romania. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed by reverse transcription polymerase chain reaction (RT-PCR) on the lung tissue which was obtained during autopsy. This case provides the opportunity to study the natural evolution of COVID-19 pneumonia in a young person with clinical signs of pneumonia but without associated comorbidities. The patient had not received any treatment. The histopathological examination of the lung revealed a process of productive proliferation, proteinaceous and fibrin-macrophagic interalveolar spaces exudate, and lesions consistent with vasculitis. In the heart, we identified a cardiac thrombus. These changes are likely to suggest an advanced natural evolution of SARS-CoV-2 virus infection.
  • |Adult[MESH]
  • |Autopsy[MESH]
  • |Betacoronavirus[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coronavirus Infections/diagnosis/*physiopathology/*virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Kidney/pathology[MESH]
  • |Liver/pathology[MESH]
  • |Lung/pathology/*virology[MESH]
  • |Myocardium/pathology[MESH]
  • |Pancreas/pathology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*physiopathology/*virology[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction[MESH]
  • |Romania[MESH]
  • |Thrombosis/pathology/virology[MESH]

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  • suck abstract from ncbi

    209 1.61 2020