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10.1038/s41591-020-1021-2 http://scihub22266oqcxt.onion/10.1038/s41591-020-1021-2 32747830!7809634!32747830     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2020 ; 26 (10): 1609-1615 Nephropedia Template TP {{tp|p=32747830|t=2020. Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection |pdf=|usr=}}{{32747830}} gab.com Text Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=32747830 #FOAvip Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and public health strategies. Viral-host interactions can guide discovery of disease regulators, and protein structure function analysis points to several immune pathways, including complement and coagulation, as targets of coronaviruses. To determine whether conditions associated with dysregulated complement or coagulation systems impact disease, we performed a retrospective observational study and found that history of macular degeneration (a proxy for complement-activation disorders) and history of coagulation disorders (thrombocytopenia, thrombosis and hemorrhage) are risk factors for SARS-CoV-2-associated morbidity and mortality-effects that are independent of age, sex or history of smoking. Transcriptional profiling of nasopharyngeal swabs demonstrated that in addition to type-I interferon and interleukin-6-dependent inflammatory responses, infection results in robust engagement of the complement and coagulation pathways. Finally, in a candidate-driven genetic association study of severe SARS-CoV-2 disease, we identified putative complement and coagulation-associated loci including missense, eQTL and sQTL variants of critical complement and coagulation regulators. In addition to providing evidence that complement function modulates SARS-CoV-2 infection outcome, the data point to putative transcriptional genetic markers of susceptibility. The results highlight the value of using a multimodal analytical approach to reveal determinants and predictors of immunity, susceptibility and clinical outcome associated with infection. Twit Text FOAVip Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=32747830 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32747830 #FOAvip English Wikipedia <ref>{{Cite pmid|32747830}}</ref> Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection #MMPMID32747830 Ramlall V; Thangaraj PM; Meydan C; Foox J; Butler D; Kim J; May B; De Freitas JK; Glicksberg BS; Mason CE; Tatonetti NP; Shapira SD Nat Med 2020[Oct]; 26 (10): 1609-1615 PMID32747830show ga Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and public health strategies. Viral-host interactions can guide discovery of disease regulators, and protein structure function analysis points to several immune pathways, including complement and coagulation, as targets of coronaviruses. To determine whether conditions associated with dysregulated complement or coagulation systems impact disease, we performed a retrospective observational study and found that history of macular degeneration (a proxy for complement-activation disorders) and history of coagulation disorders (thrombocytopenia, thrombosis and hemorrhage) are risk factors for SARS-CoV-2-associated morbidity and mortality-effects that are independent of age, sex or history of smoking. Transcriptional profiling of nasopharyngeal swabs demonstrated that in addition to type-I interferon and interleukin-6-dependent inflammatory responses, infection results in robust engagement of the complement and coagulation pathways. Finally, in a candidate-driven genetic association study of severe SARS-CoV-2 disease, we identified putative complement and coagulation-associated loci including missense, eQTL and sQTL variants of critical complement and coagulation regulators. In addition to providing evidence that complement function modulates SARS-CoV-2 infection outcome, the data point to putative transcriptional genetic markers of susceptibility. The results highlight the value of using a multimodal analytical approach to reveal determinants and predictors of immunity, susceptibility and clinical outcome associated with infection. |Adult[MESH] |Age Factors[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Betacoronavirus[MESH] |Blood Coagulation Disorders/epidemiology[MESH] |Blood Coagulation/genetics[MESH] |COVID-19[MESH] |Complement Activation/genetics/*immunology[MESH] |Coronavirus Infections/blood/genetics/immunology/*mortality[MESH] |Diabetes Mellitus, Type 2/epidemiology[MESH] |Female[MESH] |Gene Expression[MESH] |Hemorrhage/blood/*epidemiology/immunology[MESH] |Hereditary Complement Deficiency Diseases/epidemiology/immunology[MESH] |Humans[MESH] |Hypertension/epidemiology[MESH] |Intubation, Intratracheal[MESH] |Macular Degeneration/*epidemiology[MESH] |Male[MESH] |Middle Aged[MESH] |New York City/epidemiology[MESH] |Obesity/epidemiology[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/genetics/immunology/*mortality[MESH] |Proportional Hazards Models[MESH] |Respiration, Artificial[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH] |Sex Factors[MESH] |Thrombocytopenia/blood/*epidemiology[MESH]Immune complement and coagulation dysfunction in adverse outcomes of S(epmc).pdf DeepDyve Pubget Overpricing