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10.1038/s41401-020-0485-4 http://scihub22266oqcxt.onion/10.1038/s41401-020-0485-4 32747721!7396720!32747721     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Pharmacol+Sin 2020 ; 41 (9): 1141-1149 Nephropedia Template TP {{tp|p=32747721|t=2020. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 |pdf=|usr=}}{{32747721}} gab.com Text Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 JO: Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=32747721 #FOAvip Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein. Twit Text FOAVip Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 ????Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=32747721 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32747721 #FOAvip English Wikipedia <ref>{{Cite pmid|32747721}}</ref> Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 #MMPMID32747721 Huang Y; Yang C; Xu XF; Xu W; Liu SW Acta Pharmacol Sin 2020[Sep]; 41 (9): 1141-1149 PMID32747721show ga Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein. |*Betacoronavirus/drug effects/physiology[MESH] |*Coronavirus Infections/drug therapy/virology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/drug therapy/virology[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19[MESH] |Drug Discovery/methods[MESH] |Humans[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/*physiology[MESH]Structural and functional properties of SARS-CoV-2 spike protein: pote(epmc).pdf DeepDyve Pubget Overpricing