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10.1016/j.ebiom.2020.102925 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2020.102925 32745993!7397705!32745993     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EBioMedicine 2020 ; 58 (ä): 102925 Nephropedia Template TP {{tp|p=32745993|t=2020. Vascular occlusion by neutrophil extracellular traps in COVID-19 |pdf=|usr=}}{{32745993}} gab.com Text Vascular occlusion by neutrophil extracellular traps in COVID-19 JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=32745993 #FOAvip BACKGROUND: Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood. METHODS: Samples were donated from hospitalized patients. Sera, plasma, and autopsy-derived tissue sections were examined employing flow cytometry, enzyme-linked immunosorbent assays, and immunohistochemistry. PATIENT FINDINGS: Here, we show that severe COVID-19 is characterized by a highly pronounced formation of neutrophil extracellular traps (NETs) inside the micro-vessels. Intravascular aggregation of NETs leads to rapid occlusion of the affected vessels, disturbed microcirculation, and organ damage. In severe COVID-19, neutrophil granulocytes are strongly activated and adopt a so-called low-density phenotype, prone to spontaneously form NETs. In accordance, markers indicating NET turnover are consistently increased in COVID-19 and linked to disease severity. Histopathology of the lungs and other organs from COVID-19 patients showed congestions of numerous micro-vessels by aggregated NETs associated with endothelial damage. INTERPRETATION: These data suggest that organ dysfunction in severe COVID-19 is associated with excessive NET formation and vascular damage. FUNDING: Deutsche Forschungsgemeinschaft (DFG), EU, Volkswagen-Stiftung. Twit Text FOAVip Vascular occlusion by neutrophil extracellular traps in COVID-19 ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=32745993 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32745993 #FOAvip English Wikipedia <ref>{{Cite pmid|32745993}}</ref> Vascular occlusion by neutrophil extracellular traps in COVID-19 #MMPMID32745993 Leppkes M; Knopf J; Naschberger E; Lindemann A; Singh J; Herrmann I; Sturzl M; Staats L; Mahajan A; Schauer C; Kremer AN; Volkl S; Amann K; Evert K; Falkeis C; Wehrfritz A; Rieker RJ; Hartmann A; Kremer AE; Neurath MF; Munoz LE; Schett G; Herrmann M EBioMedicine 2020[Aug]; 58 (ä): 102925 PMID32745993show ga BACKGROUND: Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood. METHODS: Samples were donated from hospitalized patients. Sera, plasma, and autopsy-derived tissue sections were examined employing flow cytometry, enzyme-linked immunosorbent assays, and immunohistochemistry. PATIENT FINDINGS: Here, we show that severe COVID-19 is characterized by a highly pronounced formation of neutrophil extracellular traps (NETs) inside the micro-vessels. Intravascular aggregation of NETs leads to rapid occlusion of the affected vessels, disturbed microcirculation, and organ damage. In severe COVID-19, neutrophil granulocytes are strongly activated and adopt a so-called low-density phenotype, prone to spontaneously form NETs. In accordance, markers indicating NET turnover are consistently increased in COVID-19 and linked to disease severity. Histopathology of the lungs and other organs from COVID-19 patients showed congestions of numerous micro-vessels by aggregated NETs associated with endothelial damage. INTERPRETATION: These data suggest that organ dysfunction in severe COVID-19 is associated with excessive NET formation and vascular damage. FUNDING: Deutsche Forschungsgemeinschaft (DFG), EU, Volkswagen-Stiftung. |COVID-19[MESH] |Cells, Cultured[MESH] |Coronavirus Infections/complications/metabolism/*pathology[MESH] |Endothelium, Vascular/metabolism/pathology[MESH] |Extracellular Traps/*metabolism[MESH] |Humans[MESH] |Microvessels/metabolism/*pathology[MESH] |Neutrophils/*metabolism/pathology[MESH] |Pandemics[MESH] |Pneumonia, Viral/complications/metabolism/*pathology[MESH]Vascular occlusion by neutrophil extracellular traps in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing