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10.1016/j.cellimm.2020.104187 http://scihub22266oqcxt.onion/10.1016/j.cellimm.2020.104187 32745670!7386780!32745670     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Immunol 2020 ; 356 (ä): 104187 Nephropedia Template TP {{tp|p=32745670|t=2020. New disease old vaccine: Is recombinant BCG vaccine an answer for COVID-19?|pdf=|usr=}}{{32745670}} gab.com Text New disease old vaccine: Is recombinant BCG vaccine an answer for COVID-19 JO: Cell Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32745670 #FOAvip Mycobacterium bovis BCG, a live attenuated tuberculosis vaccine offers protection against disseminated TB in children. BCG exhibits heterologous protective effects against unrelated infections and reduces infant mortality due to non-mycobacterial infections. Recent reports have suggested that BCG vaccination might have protective effects against COVID-19, however it is highly unlikely that BCG vaccine in its current form can offer complete protection against SARS-CoV-2 infection due to the lack of specific immunity. Nonetheless, recombinant BCG strains expressing antigens of SARS-CoV-2 may offer protection against COVID-19 due to the activation of innate as well as specific adaptive immune response. Further proven safety records of BCG in humans, its adjuvant activity and low cost manufacturing makes it a frontrunner in the vaccine development to stop this pandemic. In this review we discuss about the heterologous effects of BCG, induction of trained immunity and its implication in development of a potential vaccine against COVID-19 pandemic. Twit Text FOAVip New disease old vaccine: Is recombinant BCG vaccine an answer for COVID-19 ????Cell Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32745670 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32745670 #FOAvip English Wikipedia <ref>{{Cite pmid|32745670}}</ref> New disease old vaccine: Is recombinant BCG vaccine an answer for COVID-19? #MMPMID32745670 Gupta PK Cell Immunol 2020[Oct]; 356 (ä): 104187 PMID32745670show ga Mycobacterium bovis BCG, a live attenuated tuberculosis vaccine offers protection against disseminated TB in children. BCG exhibits heterologous protective effects against unrelated infections and reduces infant mortality due to non-mycobacterial infections. Recent reports have suggested that BCG vaccination might have protective effects against COVID-19, however it is highly unlikely that BCG vaccine in its current form can offer complete protection against SARS-CoV-2 infection due to the lack of specific immunity. Nonetheless, recombinant BCG strains expressing antigens of SARS-CoV-2 may offer protection against COVID-19 due to the activation of innate as well as specific adaptive immune response. Further proven safety records of BCG in humans, its adjuvant activity and low cost manufacturing makes it a frontrunner in the vaccine development to stop this pandemic. In this review we discuss about the heterologous effects of BCG, induction of trained immunity and its implication in development of a potential vaccine against COVID-19 pandemic. |BCG Vaccine/*therapeutic use[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/*prevention & control[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Immunologic Memory[MESH] |Pandemics/*prevention & control[MESH] |Pneumonia, Viral/*prevention & control[MESH] |SARS-CoV-2[MESH]New disease old vaccine: Is recombinant BCG vaccine an answer for COVI(epmc).pdf DeepDyve Pubget Overpricing