Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.ijbiomac.2020.07.235 http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2020.07.235 32745548!7395220!32745548     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Biol+Macromol 2020 ; 164 (ä): 1693-1703 Nephropedia Template TP {{tp|p=32745548|t=2020. Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening |pdf=|usr=}}{{32745548}} gab.com Text Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening JO: Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=32745548 #FOAvip The global health emergency generated by coronavirus disease 2019 (COVID-19) has prompted the search for preventive and therapeutic treatments for its pathogen, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are many potential targets for drug discovery and development to tackle this disease. One of these targets is the main protease, Mpro or 3CLpro, which is highly conserved among coronaviruses. 3CLpro is an essential player in the viral replication cycle, processing the large viral polyproteins and rendering the individual proteins functional. We report a biophysical characterization of the structural stability and the catalytic activity of 3CLpro from SARS-CoV-2, from which a suitable experimental in vitro molecular screening procedure has been designed. By screening of a small chemical library consisting of about 150 compounds, the natural product quercetin was identified as reasonably potent inhibitor of SARS-CoV-2 3CLpro (K(i) ~ 7 muM). Quercetin could be shown to interact with 3CLpro using biophysical techniques and bind to the active site in molecular simulations. Quercetin, with well-known pharmacokinetic and ADMET properties, can be considered as a good candidate for further optimization and development, or repositioned for COVID-19 therapeutic treatment. Twit Text FOAVip Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening ????Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=32745548 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32745548 #FOAvip English Wikipedia <ref>{{Cite pmid|32745548}}</ref> Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening #MMPMID32745548 Abian O; Ortega-Alarcon D; Jimenez-Alesanco A; Ceballos-Laita L; Vega S; Reyburn HT; Rizzuti B; Velazquez-Campoy A Int J Biol Macromol 2020[Dec]; 164 (ä): 1693-1703 PMID32745548show ga The global health emergency generated by coronavirus disease 2019 (COVID-19) has prompted the search for preventive and therapeutic treatments for its pathogen, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are many potential targets for drug discovery and development to tackle this disease. One of these targets is the main protease, Mpro or 3CLpro, which is highly conserved among coronaviruses. 3CLpro is an essential player in the viral replication cycle, processing the large viral polyproteins and rendering the individual proteins functional. We report a biophysical characterization of the structural stability and the catalytic activity of 3CLpro from SARS-CoV-2, from which a suitable experimental in vitro molecular screening procedure has been designed. By screening of a small chemical library consisting of about 150 compounds, the natural product quercetin was identified as reasonably potent inhibitor of SARS-CoV-2 3CLpro (K(i) ~ 7 muM). Quercetin could be shown to interact with 3CLpro using biophysical techniques and bind to the active site in molecular simulations. Quercetin, with well-known pharmacokinetic and ADMET properties, can be considered as a good candidate for further optimization and development, or repositioned for COVID-19 therapeutic treatment. |Antiviral Agents/chemistry/*pharmacology[MESH] |Betacoronavirus/chemistry/drug effects/*enzymology[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Catalytic Domain/drug effects[MESH] |Coronavirus 3C Proteases[MESH] |Coronavirus Infections/drug therapy/virology[MESH] |Cysteine Endopeptidases/*chemistry/metabolism[MESH] |Drug Discovery[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH] |Pandemics[MESH] |Pneumonia, Viral/drug therapy/virology[MESH] |Protease Inhibitors/chemistry/*pharmacology[MESH] |Protein Conformation/drug effects[MESH] |Protein Unfolding[MESH] |Quercetin/chemistry/*pharmacology[MESH] |SARS-CoV-2[MESH]Structural stability of SARS-CoV-2 3CLpro and identification of querce(epmc).pdf DeepDyve Pubget Overpricing