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10.1016/j.hemonc.2020.07.005

http://scihub22266oqcxt.onion/10.1016/j.hemonc.2020.07.005
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suck abstract from ncbi


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pmid32745466      Hematol+Oncol+Stem+Cell+Ther 2022 ; 15 (2): 45-53
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  • The Risk and Prognosis of COVID-19 Infection in Cancer Patients: A Systematic Review and Meta-Analysis #MMPMID32745466
  • ElGohary GM; Hashmi S; Styczynski J; Kharfan-Dabaja MA; Alblooshi RM; de la Camara R; Mohmed S; Alshaibani A; Cesaro S; Abd El-Aziz N; Almaghrabi R; Gergis U; Majhail NS; El-Gohary Y; Chemaly RF; Aljurf M; El Fakih R
  • Hematol Oncol Stem Cell Ther 2022[Jun]; 15 (2): 45-53 PMID32745466show ga
  • Numerous studies have been published regarding outcomes of cancer patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus causing the coronavirus disease 2019 (COVID-19) infection. However, most of these are single-center studies with a limited number of patients. To better assess the outcomes of this new infection in this subgroup of susceptible patients, we performed a systematic review and meta-analysis to evaluate the impact of COVID-19 infection on cancer patients. We performed a literature search using PubMed, Web of Science, and Scopus for studies that reported the risk of infection and complications of COVID-19 in cancer patients and retrieved 22 studies (1018 cancer patients). The analysis showed that the frequency of cancer among patients with confirmed COVID-19 was 2.1% (95% confidence interval [CI]: 1.3-3) in the overall cohort. These patients had a mortality of 21.1% (95% CI: 14.7-27.6), severe/critical disease rate of 45.4% (95% CI: 37.4-53.3), intensive care unit (ICU) admission rate of 14.5% (95% CI: 8.5-20.4), and mechanical ventilation rate of 11.7% (95% CI: 5.5-18). The double-arm analysis showed that cancer patients had a higher risk of mortality (odds ratio [OR]=3.23, 95% CI: 1.71-6.13), severe/critical disease (OR=3.91, 95% CI: 2.70-5.67), ICU admission (OR=3.10, 95% CI: 1.85-5.17), and mechanical ventilation (OR=4.86, 95% CI: 1.27-18.65) than non-cancer patients. Furthermore, cancer patients had significantly lower platelet levels and higher D-dimer levels, C-reactive protein levels, and prothrombin time. In conclusion, these results indicate that cancer patients are at a higher risk of COVID-19 infection-related complications. Therefore, cancer patients need diligent preventive care measures and aggressive surveillance for earlier detection of COVID-19 infection.
  • |*COVID-19/complications[MESH]
  • |*Neoplasms/complications[MESH]
  • |Humans[MESH]
  • |Intensive Care Units[MESH]
  • |Prognosis[MESH]
  • |Respiration, Artificial[MESH]


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