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10.1007/s11154-020-09573-6 http://scihub22266oqcxt.onion/10.1007/s11154-020-09573-6 32743793!7395898!32743793     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Rev+Endocr+Metab+Disord 2020 ; 21 (4): 451-463 Nephropedia Template TP {{tp|p=32743793|t=2020. COVID-19 and diabetes mellitus: how one pandemic worsens the other |pdf=|usr=}}{{32743793}} gab.com Text COVID-19 and diabetes mellitus: how one pandemic worsens the other JO: Rev Endocr Metab Disord http://www.kidney.de/pget.php?&tw=1&pmid=32743793 #FOAvip In light of the most challenging public health crisis of modern history, COVID-19 mortality continues to rise at an alarming rate. Patients with co-morbidities such as hypertension, cardiovascular disease, and diabetes mellitus (DM) seem to be more prone to severe symptoms and appear to have a higher mortality rate. In this review, we elucidate suggested mechanisms underlying the increased susceptibility of patients with diabetes to infection with SARS-CoV-2 with a more severe COVID-19 disease. The worsened prognosis of COVID-19 patients with DM can be attributed to a facilitated viral uptake assisted by the host's receptor angiotensin-converting enzyme 2 (ACE2). It can also be associated with a higher basal level of pro-inflammatory cytokines present in patients with diabetes, which enables a hyperinflammatory "cytokine storm" in response to the virus. This review also suggests a link between elevated levels of IL-6 and AMPK/mTOR signaling pathway and their role in exacerbating diabetes-induced complications and insulin resistance. If further studied, these findings could help identify novel therapeutic intervention strategies for patients with diabetes comorbid with COVID-19. Twit Text FOAVip COVID-19 and diabetes mellitus: how one pandemic worsens the other ????Rev Endocr Metab Disord http://www.kidney.de/pget.php?&tw=1&pmid=32743793 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32743793 #FOAvip English Wikipedia <ref>{{Cite pmid|32743793}}</ref> COVID-19 and diabetes mellitus: how one pandemic worsens the other #MMPMID32743793 Azar WS; Njeim R; Fares AH; Azar NS; Azar ST; El Sayed M; Eid AA Rev Endocr Metab Disord 2020[Dec]; 21 (4): 451-463 PMID32743793show ga In light of the most challenging public health crisis of modern history, COVID-19 mortality continues to rise at an alarming rate. Patients with co-morbidities such as hypertension, cardiovascular disease, and diabetes mellitus (DM) seem to be more prone to severe symptoms and appear to have a higher mortality rate. In this review, we elucidate suggested mechanisms underlying the increased susceptibility of patients with diabetes to infection with SARS-CoV-2 with a more severe COVID-19 disease. The worsened prognosis of COVID-19 patients with DM can be attributed to a facilitated viral uptake assisted by the host's receptor angiotensin-converting enzyme 2 (ACE2). It can also be associated with a higher basal level of pro-inflammatory cytokines present in patients with diabetes, which enables a hyperinflammatory "cytokine storm" in response to the virus. This review also suggests a link between elevated levels of IL-6 and AMPK/mTOR signaling pathway and their role in exacerbating diabetes-induced complications and insulin resistance. If further studied, these findings could help identify novel therapeutic intervention strategies for patients with diabetes comorbid with COVID-19. |*Comorbidity[MESH] |*Pandemics[MESH] |COVID-19[MESH] |Coronavirus Infections/epidemiology/*immunology[MESH] |Diabetes Mellitus/epidemiology/*immunology[MESH] |Disease Susceptibility/epidemiology/*immunology[MESH] |Humans[MESH]COVID-19 and diabetes mellitus: how one pandemic worsens the other (epmc).pdf DeepDyve Pubget Overpricing