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10.7717/peerj.9587 http://scihub22266oqcxt.onion/10.7717/peerj.9587 32742818!7380272!32742818     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PeerJ 2020 ; 8 (ä): e9587 Nephropedia Template TP {{tp|p=32742818|t=2020. RdRp mutations are associated with SARS-CoV-2 genome evolution |pdf=|usr=}}{{32742818}} gab.com Text RdRp mutations are associated with SARS-CoV-2 genome evolution JO: PeerJ http://www.kidney.de/pget.php?&tw=1&pmid=32742818 #FOAvip COVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of the viral genome over time as it spread across the world. An important question that still needs to be answered is whether any of the common mutations affect the viral properties, and therefore the disease characteristics. Therefore, we sought to understand the effects of mutations in RNA-dependent RNA polymerase (RdRp), particularly the common 14408C>T mutation, on mutation rate and viral spread. By focusing on mutations in the slowly evolving M or E genes, we aimed to minimize the effects of selective pressure. Our results indicate that 14408C>T mutation increases the mutation rate, while the third-most common RdRp mutation, 15324C>T, has the opposite effect. It is possible that 14408C>T mutation may have contributed to the dominance of its co-mutations in Europe and elsewhere. Twit Text FOAVip RdRp mutations are associated with SARS-CoV-2 genome evolution ????PeerJ http://www.kidney.de/pget.php?&tw=1&pmid=32742818 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32742818 #FOAvip English Wikipedia <ref>{{Cite pmid|32742818}}</ref> RdRp mutations are associated with SARS-CoV-2 genome evolution #MMPMID32742818 Eskier D; Karakulah G; Suner A; Oktay Y PeerJ 2020[]; 8 (ä): e9587 PMID32742818show ga COVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of the viral genome over time as it spread across the world. An important question that still needs to be answered is whether any of the common mutations affect the viral properties, and therefore the disease characteristics. Therefore, we sought to understand the effects of mutations in RNA-dependent RNA polymerase (RdRp), particularly the common 14408C>T mutation, on mutation rate and viral spread. By focusing on mutations in the slowly evolving M or E genes, we aimed to minimize the effects of selective pressure. Our results indicate that 14408C>T mutation increases the mutation rate, while the third-most common RdRp mutation, 15324C>T, has the opposite effect. It is possible that 14408C>T mutation may have contributed to the dominance of its co-mutations in Europe and elsewhere. äRdRp mutations are associated with SARS-CoV-2 genome evolution (epmc).pdf DeepDyve Pubget Overpricing