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10.1159/000509352 http://scihub22266oqcxt.onion/10.1159/000509352 32739920!7845419!32739920     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32739920&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Nephron 2020 ; 144 (12): 655-661 Nephropedia Template TP {{tp|p=32739920|t=2020. Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury |pdf=|usr=}}{{32739920}} gab.com Text Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury JO: Nephron http://www.kidney.de/pget.php?&tw=1&pmid=32739920 #FOAvip Assessment of kidney function is primarily based on urine output and Creatinine (Cr)-based methods to estimate glomerular filtration rate (GFR). The latter is confounded as Cr is not exclusively filtered by the kidney and rises relatively late after the onset of acute kidney injury (AKI). This leads to delays in recognition of reduced kidney function and diagnosis of AKI, particularly in critically ill patients where kidney function can change rapidly. The gold standard methods of GFR determination, such as inulin or iohexol clearance, are labor intensive and unfeasible in acute clinical settings. Proenkephalin A 119-159 (PENK) has been intensively studied as a novel biomarker of kidney function. PENK belongs to the enkephalin peptide family and is freely filtrated in the glomerulus. Plasma PENK concentration appears to correlate strongly with GFR. Moreover, increased plasma PENK concentrations are found to be associated with long-term kidney outcomes and mortality. In this review, we summarize the role of PENK in assessment of kidney function and its capacity to predict various clinical outcomes. Twit Text FOAVip Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury ????Nephron http://www.kidney.de/pget.php?&tw=1&pmid=32739920 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32739920 #FOAvip English Wikipedia <ref>{{Cite pmid|32739920}}</ref> Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury #MMPMID32739920 Khorashadi M; Beunders R; Pickkers P; Legrand M Nephron 2020[]; 144 (12): 655-661 PMID32739920show ga Assessment of kidney function is primarily based on urine output and Creatinine (Cr)-based methods to estimate glomerular filtration rate (GFR). The latter is confounded as Cr is not exclusively filtered by the kidney and rises relatively late after the onset of acute kidney injury (AKI). This leads to delays in recognition of reduced kidney function and diagnosis of AKI, particularly in critically ill patients where kidney function can change rapidly. The gold standard methods of GFR determination, such as inulin or iohexol clearance, are labor intensive and unfeasible in acute clinical settings. Proenkephalin A 119-159 (PENK) has been intensively studied as a novel biomarker of kidney function. PENK belongs to the enkephalin peptide family and is freely filtrated in the glomerulus. Plasma PENK concentration appears to correlate strongly with GFR. Moreover, increased plasma PENK concentrations are found to be associated with long-term kidney outcomes and mortality. In this review, we summarize the role of PENK in assessment of kidney function and its capacity to predict various clinical outcomes. |*Glomerular Filtration Rate[MESH] |Acute Kidney Injury/*blood/physiopathology[MESH] |Biomarkers/blood[MESH] |Critical Illness[MESH] |Enkephalins/*blood[MESH] |Humans[MESH] |Kidney/physiopathology[MESH]Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acut(epmc).pdf DeepDyve Pubget Overpricing