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10.1016/j.jri.2020.103180

http://scihub22266oqcxt.onion/10.1016/j.jri.2020.103180
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suck abstract from ncbi


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pmid32739645      J+Reprod+Immunol 2020 ; 142 (ä): 103180
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  • What immunological and hormonal protective factors lower the risk of COVID-19 related deaths in pregnant women? #MMPMID32739645
  • Berhan Y
  • J Reprod Immunol 2020[Nov]; 142 (ä): 103180 PMID32739645show ga
  • Despite anticipated increased risk of COVID-19 and increased expression of the SARS CoV-2 receptor (ACE2), the relatively low mortality of pregnant women with COVID-19 has been an area of wonder. The immunological changes predominantly inclining to anti-inflammatory state, which is augmented by placental hormones' immune modulating action, looks against with COVID-19 inflammatory reaction leading to cytokine storm and multiple organ failure. Unlike many other viral infections, the bilateral immune activation of COVID-19 may preferentially make pregnant women at low risk. Taking the physiological advantage of pregnant women, potential clinical trials are proposed. Quite a large number of epidemiological and obstetrics related studies have addressed the cases of women with COVID-19. However, to the best of the author's knowledge, little is done to explore the physiological internal milieu of pregnant women in relation to COVID-19. This review provides an insight into how the hormonal and immunological changes in pregnancy potentially reduce SARS-CoV-2-mediated inflammatory response.
  • |Adult[MESH]
  • |COVID-19/*complications/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Pregnancy[MESH]
  • |Pregnancy Complications, Infectious/*immunology/*metabolism/*mortality[MESH]
  • |Risk Factors[MESH]


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