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10.1016/j.ejphar.2020.173450 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2020.173450 32739174!7834013!32739174     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32739174&cmd=llinks): Failed to open stream: HTTP request failed! 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Approaches and advances in the development of potential therapeutic targets and antiviral agents for the management of SARS-CoV-2 infection |pdf=|usr=}}{{32739174}} gab.com Text Approaches and advances in the development of potential therapeutic targets and antiviral agents for the management of SARS-CoV-2 infection JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32739174 #FOAvip Virus onslaughts continue to spread fear and cause rampage across the world every now and then. The twenty first century is yet again witnessing a gross global pandemic, Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Globally no vaccines or drug specific to COVID-19 is available. Corona viruses have been in mutual relationship with humans and other hosts over many decades though aggressive zoonotic strains have caused havoc. Zoonotic emergent corona viruses prior to SARS-COV-2 included severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), with the former leading to aggressive infectious spread and the later with high mortality rate. Although they emerged in the early period of the twenty first century, resilient biomedical and expertise in pharmaceutical domain could not appropriate any proprietary therapeutics. Studies envisaged towards curtailing their spread employed different stages of the virus life cycle with all zoonotic coronaviruses (CoVs) sharing genomic and structural similarities. Hence the strategies against SARS-CoV and MERS-CoV could prove effective against the recent outbreak of SAR-CoV-2. The review unravels key events involved in the lifecycle of SARS-CoV-2 while highlighting the possible avenues of therapy. The review also holds the scope in better understanding a broad-spectrum antivirals, monoclonal antibodies and small molecule inhibitors against viral glycoproteins, host cell receptor, viral mRNA synthesis, RNA-dependent RNA polymerase (RdRp) and viral proteases in order to design and develop antiviral drugs for SARS-CoV-2. Twit Text FOAVip Approaches and advances in the development of potential therapeutic targets and antiviral agents for the management of SARS-CoV-2 infection ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32739174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32739174 #FOAvip English Wikipedia <ref>{{Cite pmid|32739174}}</ref> Approaches and advances in the development of potential therapeutic targets and antiviral agents for the management of SARS-CoV-2 infection #MMPMID32739174 Krishna G; Pillai VS; Veettil MV Eur J Pharmacol 2020[Oct]; 885 (ä): 173450 PMID32739174show ga Virus onslaughts continue to spread fear and cause rampage across the world every now and then. The twenty first century is yet again witnessing a gross global pandemic, Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Globally no vaccines or drug specific to COVID-19 is available. Corona viruses have been in mutual relationship with humans and other hosts over many decades though aggressive zoonotic strains have caused havoc. Zoonotic emergent corona viruses prior to SARS-COV-2 included severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), with the former leading to aggressive infectious spread and the later with high mortality rate. Although they emerged in the early period of the twenty first century, resilient biomedical and expertise in pharmaceutical domain could not appropriate any proprietary therapeutics. Studies envisaged towards curtailing their spread employed different stages of the virus life cycle with all zoonotic coronaviruses (CoVs) sharing genomic and structural similarities. Hence the strategies against SARS-CoV and MERS-CoV could prove effective against the recent outbreak of SAR-CoV-2. The review unravels key events involved in the lifecycle of SARS-CoV-2 while highlighting the possible avenues of therapy. The review also holds the scope in better understanding a broad-spectrum antivirals, monoclonal antibodies and small molecule inhibitors against viral glycoproteins, host cell receptor, viral mRNA synthesis, RNA-dependent RNA polymerase (RdRp) and viral proteases in order to design and develop antiviral drugs for SARS-CoV-2. |*Drug Discovery[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology/therapeutic use[MESH] |Betacoronavirus/drug effects[MESH] |COVID-19[MESH] |Coronavirus Infections/diagnosis/*drug therapy[MESH] |Humans[MESH] |Molecular Targeted Therapy/*methods[MESH] |Pandemics[MESH] |Pneumonia, Viral/diagnosis/*drug therapy[MESH]Approaches and advances in the development of potential therapeutic ta(epmc).pdf DeepDyve Pubget Overpricing