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10.1016/j.ijsu.2020.07.017 http://scihub22266oqcxt.onion/10.1016/j.ijsu.2020.07.017 32738546!7388795!32738546     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Surg 2020 ; 81 (ä): 47-54 Nephropedia Template TP {{tp|p=32738546|t=2020. Trauma of major surgery: A global problem that is not going away |pdf=|usr=}}{{32738546}} gab.com Text Trauma of major surgery: A global problem that is not going away JO: Int J Surg http://www.kidney.de/pget.php?&tw=1&pmid=32738546 #FOAvip Globally, a staggering 310 million major surgeries are performed each year; around 40 to 50 million in USA and 20 million in Europe. It is estimated that 1-4% of these patients will die, up to 15% will have serious postoperative morbidity, and 5-15% will be readmitted within 30 days. An annual global mortality of around 8 million patients places major surgery comparable with the leading causes of death from cardiovascular disease and stroke, cancer and injury. If surgical complications were classified as a pandemic, like HIV/AIDS or coronavirus (COVID-19), developed countries would work together and devise an immediate action plan and allocate resources to address it. Seeking to reduce preventable deaths and post-surgical complications would save billions of dollars in healthcare costs. Part of the global problem resides in differences in institutional practice patterns in high- and low-income countries, and part from a lack of effective perioperative drug therapies to protect the patient from surgical stress. We briefly review the history of surgical stress and provide a path forward from a systems-based approach. Key to progress is recognizing that the anesthetized brain is still physiologically 'awake' and responsive to the sterile stressors of surgery. New intravenous drug therapies are urgently required after anesthesia and before the first incision to prevent the brain from switching to sympathetic overdrive and activating secondary injury progression such as hyperinflammation, coagulopathy, immune activation and metabolic dysfunction. A systems-based approach targeting central nervous system-mitochondrial coupling may help drive research to improve outcomes following major surgery in civilian and military medicine. Twit Text FOAVip Trauma of major surgery: A global problem that is not going away ????Int J Surg http://www.kidney.de/pget.php?&tw=1&pmid=32738546 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32738546 #FOAvip English Wikipedia <ref>{{Cite pmid|32738546}}</ref> Trauma of major surgery: A global problem that is not going away #MMPMID32738546 Dobson GP Int J Surg 2020[Sep]; 81 (ä): 47-54 PMID32738546show ga Globally, a staggering 310 million major surgeries are performed each year; around 40 to 50 million in USA and 20 million in Europe. It is estimated that 1-4% of these patients will die, up to 15% will have serious postoperative morbidity, and 5-15% will be readmitted within 30 days. An annual global mortality of around 8 million patients places major surgery comparable with the leading causes of death from cardiovascular disease and stroke, cancer and injury. If surgical complications were classified as a pandemic, like HIV/AIDS or coronavirus (COVID-19), developed countries would work together and devise an immediate action plan and allocate resources to address it. Seeking to reduce preventable deaths and post-surgical complications would save billions of dollars in healthcare costs. Part of the global problem resides in differences in institutional practice patterns in high- and low-income countries, and part from a lack of effective perioperative drug therapies to protect the patient from surgical stress. We briefly review the history of surgical stress and provide a path forward from a systems-based approach. Key to progress is recognizing that the anesthetized brain is still physiologically 'awake' and responsive to the sterile stressors of surgery. New intravenous drug therapies are urgently required after anesthesia and before the first incision to prevent the brain from switching to sympathetic overdrive and activating secondary injury progression such as hyperinflammation, coagulopathy, immune activation and metabolic dysfunction. A systems-based approach targeting central nervous system-mitochondrial coupling may help drive research to improve outcomes following major surgery in civilian and military medicine. |Global Health[MESH] |Glycocalyx/physiology[MESH] |Humans[MESH] |Hypothalamo-Hypophyseal System/physiology[MESH] |Mitochondria/physiology[MESH] |Pituitary-Adrenal System/physiology[MESH] |Postoperative Complications/*etiology/prevention & control[MESH] |Stress, Physiological[MESH]Trauma of major surgery: A global problem that is not going away (epmc).pdf DeepDyve Pubget Overpricing