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10.1016/j.ijantimicag.2020.106118

http://scihub22266oqcxt.onion/10.1016/j.ijantimicag.2020.106118
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suck abstract from ncbi


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pmid32738305      Int+J+Antimicrob+Agents 2020 ; 56 (3): 106118
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  • Lactoferrin as potential preventative and adjunct treatment for COVID-19 #MMPMID32738305
  • Chang R; Ng TB; Sun WZ
  • Int J Antimicrob Agents 2020[Sep]; 56 (3): 106118 PMID32738305show ga
  • The coronavirus disease 2019 (COVID-19) pandemic is rapidly advancing across the globe despite drastic public and personal health measures. Antivirals and nutritional supplements have been proposed as potentially useful against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus that causes COVID-19, but few have been clinically established. Lactoferrin (Lf) is a naturally occurring, non-toxic glycoprotein that is orally available as a nutritional supplement and has established in vitro antiviral efficacy against a wide range of viruses, including SARS-CoV, a closely related coronavirus to SARS-CoV-2. Furthermore, Lf possesses unique immunomodulatory and anti-inflammatory effects that may be especially relevant to the pathophysiology of severe COVID-19 cases. Here we review the underlying biological mechanisms of Lf as an antiviral and immune regulator, and propose its unique potential as a preventative and adjunct treatment for COVID-19. We hope that further research and development of Lf nutritional supplementation would establish its role for COVID-19.
  • |*Pandemics/prevention & control[MESH]
  • |Anti-Inflammatory Agents/*therapeutic use[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Betacoronavirus/drug effects/immunology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/*epidemiology/prevention & control/virology[MESH]
  • |Heparan Sulfate Proteoglycans/antagonists & inhibitors/metabolism[MESH]
  • |Humans[MESH]
  • |Immunologic Factors/*therapeutic use[MESH]
  • |Interferons/agonists/biosynthesis[MESH]
  • |Lactoferrin/*therapeutic use[MESH]
  • |Pneumonia, Viral/*drug therapy/*epidemiology/prevention & control/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Virus Internalization/drug effects[MESH]


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