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10.1093/infdis/jiaa485

http://scihub22266oqcxt.onion/10.1093/infdis/jiaa485
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32738141!7454719!32738141
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suck abstract from ncbi


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pmid32738141      J+Infect+Dis 2020 ; 222 (9): 1439-1443
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  • Immunoserologic Detection and Diagnostic Relevance of Cross-Reactive Autoantibodies in Coronavirus Disease 2019 Patients #MMPMID32738141
  • Schiaffino MT; Di Natale M; Garcia-Martinez E; Navarro J; Munoz-Blanco JL; Demelo-Rodriguez P; Sanchez-Mateos P
  • J Infect Dis 2020[Oct]; 222 (9): 1439-1443 PMID32738141show ga
  • BACKGROUND: During the coronavirus disease 2019 (COVID-19) pandemic, we detected a new immunofluorescence (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed COVID-19 patients. METHODS: The IF pattern was composed of liver and gastric mucosa staining on rat kidney/liver/stomach sections. RESULTS: We describe 12 patients positive for the cross-reactive antibody, compared with a negative group of 43 hospitalized COVID-19 patients, finding association with either neurologic or thrombotic complications. In sequential pre- and post-COVID-19 serum samples, we confirmed autoAb seroconversion. CONCLUSIONS: Our data indicate that autoAb screening in COVID-19 patients may be easily performed by IF and alert for autoreactive-mediated complications such as thrombotic or neurologic events.
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Animals[MESH]
  • |Autoantibodies/*blood[MESH]
  • |COVID-19[MESH]
  • |Case-Control Studies[MESH]
  • |Coronavirus Infections/blood/complications/*immunology[MESH]
  • |Cross Reactions/immunology[MESH]
  • |Female[MESH]
  • |Ferritins/blood[MESH]
  • |Fluorescent Antibody Technique, Indirect[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nervous System Diseases/*immunology/virology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/complications/*immunology[MESH]
  • |Rats[MESH]
  • |SARS-CoV-2[MESH]
  • |Seroconversion[MESH]
  • |Serologic Tests[MESH]
  • |Thrombosis/*immunology/virology[MESH]


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