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10.1007/s15010-020-01486-5

http://scihub22266oqcxt.onion/10.1007/s15010-020-01486-5
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32737833!7393809!32737833
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suck abstract from ncbi


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pmid32737833      Infection 2020 ; 48 (5): 665-669
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  • Differences and similarities between SARS-CoV and SARS-CoV-2: spike receptor-binding domain recognition and host cell infection with support of cellular serine proteases #MMPMID32737833
  • Rossi GA; Sacco O; Mancino E; Cristiani L; Midulla F
  • Infection 2020[Oct]; 48 (5): 665-669 PMID32737833show ga
  • Novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) became pandemic by the end of March 2020. In contrast to the 2002-2003 SARS-CoV outbreak, which had a higher pathogenicity and lead to higher mortality rates, SARSCoV-2 infection appears to be much more contagious. Moreover, many SARS-CoV-2 infected patients are reported to develop low-titer neutralizing antibody and usually suffer prolonged illness, suggesting a more effective SARS-CoV-2 immune surveillance evasion than SARS-CoV. This paper summarizes the current state of art about the differences and similarities between the pathogenesis of the two coronaviruses, focusing on receptor binding domain, host cell entry and protease activation. Such differences may provide insight into possible intervention strategies to fight the pandemic.
  • |*Pandemics[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Antibodies, Viral/biosynthesis[MESH]
  • |Betacoronavirus/immunology/*pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Cathepsins/genetics/immunology[MESH]
  • |Coronavirus Infections/enzymology/*epidemiology/immunology/pathology[MESH]
  • |Enzyme Activation/immunology[MESH]
  • |Humans[MESH]
  • |Immune Evasion[MESH]
  • |Peptidyl-Dipeptidase A/genetics/immunology[MESH]
  • |Pneumonia, Viral/enzymology/*epidemiology/immunology/pathology[MESH]
  • |Protein Binding[MESH]
  • |Protein Domains[MESH]
  • |SARS-CoV-2[MESH]
  • |Serine Endopeptidases/genetics/immunology[MESH]
  • |Severe Acute Respiratory Syndrome/enzymology/*epidemiology/immunology/pathology[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/immunology/*pathogenicity[MESH]
  • |Severity of Illness Index[MESH]
  • |Spike Glycoprotein, Coronavirus/chemistry/genetics/*immunology[MESH]
  • |Virus Internalization[MESH]


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