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10.1136/jclinpath-2020-206957 http://scihub22266oqcxt.onion/10.1136/jclinpath-2020-206957 32737190!ä!32737190 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Pathol 2020 ; ä (ä): ä Nephropedia Template TP {{tp|p=32737190|t=2020. Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe |pdf=|usr=}}{{32737190}} gab.com Text Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe JO: J Clin Pathol http://www.kidney.de/pget.php?&tw=1&pmid=32737190 #FOAvip AIMS: Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak. METHODS: Fifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown to a corresponding period in 2019, in terms of tissue and/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time. RESULTS: In most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6/15), the decrease was >25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing. CONCLUSIONS: The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy. Twit Text FOAVip Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe ????J Clin Pathol http://www.kidney.de/pget.php?&tw=1&pmid=32737190 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32737190 #FOAvip English Wikipedia <ref>{{Cite pmid|32737190}}</ref> Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe #MMPMID32737190 Malapelle U; Pisapia P; Iaccarino A; Barberis M; Bellevicine C; Brunnstrom H; de Biase D; De Maglio G; Ericson Lindquist K; Fassan M; Fontanini G; Gruppioni E; Hofman P; Merkelbach-Bruse S; Molina Vila MA; Pujals A; Rapa I; Righi L; Rosell R; Schildgen O; Schildgen V; Schmitt FC; Tallini G; Vander Borght S; Vigliar E; Volante M; Wagener-Ryczek S; Weynand B; Troncone G J Clin Pathol 2020[Jul]; ä (ä): ä PMID32737190show ga AIMS: Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak. METHODS: Fifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown to a corresponding period in 2019, in terms of tissue and/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time. RESULTS: In most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6/15), the decrease was >25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing. CONCLUSIONS: The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy. äPredictive molecular pathology in the time of coronavirus disease (COV(epmc).pdf DeepDyve Pubget Overpricing