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10.1016/j.amjms.2020.07.018 http://scihub22266oqcxt.onion/10.1016/j.amjms.2020.07.018 32736832!7362851!32736832     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32736832&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Am+J+Med+Sci 2020 ; 360 (4): 338-341 Nephropedia Template TP {{tp|p=32736832|t=2020. Can a Combination of AT1R Antagonist and Vitamin D Treat the Lung Complication of COVID-19?|pdf=|usr=}}{{32736832}} gab.com Text Can a Combination of AT1R Antagonist and Vitamin D Treat the Lung Complication of COVID-19 JO: Am J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=32736832 #FOAvip Severe Acute Respiratory Distress Syndrome caused by a novel human coronavirus SARS-CoV-2 named COVID-19 and declared as a pandemic. This paper reviews the possibility of repurposing angiotensin type 1 receptor (AT1R) antagonists and vitamin D to treat COVID-19. ACE2 protein found on the cell membranes is the target of SARS-CoV-2 for entering into the host cells. Viral spike protein-binding with ACE2 down-regulates it. As ACE2 is known to protect the lung from injuries, SARS-CoV-2-induced ACE2 deficiency may expose patients to lung damage. AT1R antagonists and vitamin D increase the expression of ACE2 independently. Besides, vitamin D suppresses the compensatory increase in renin levels following the inhibition of the renin-angiotensin system by AT1R antagonists. Therefore, a combination of AT1R antagonists and vitamin D may offer protection against COVID-19 induced lung injury. Twit Text FOAVip Can a Combination of AT1R Antagonist and Vitamin D Treat the Lung Complication of COVID-19 ????Am J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=32736832 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32736832 #FOAvip English Wikipedia <ref>{{Cite pmid|32736832}}</ref> Can a Combination of AT1R Antagonist and Vitamin D Treat the Lung Complication of COVID-19? #MMPMID32736832 Rafiullah M Am J Med Sci 2020[Oct]; 360 (4): 338-341 PMID32736832show ga Severe Acute Respiratory Distress Syndrome caused by a novel human coronavirus SARS-CoV-2 named COVID-19 and declared as a pandemic. This paper reviews the possibility of repurposing angiotensin type 1 receptor (AT1R) antagonists and vitamin D to treat COVID-19. ACE2 protein found on the cell membranes is the target of SARS-CoV-2 for entering into the host cells. Viral spike protein-binding with ACE2 down-regulates it. As ACE2 is known to protect the lung from injuries, SARS-CoV-2-induced ACE2 deficiency may expose patients to lung damage. AT1R antagonists and vitamin D increase the expression of ACE2 independently. Besides, vitamin D suppresses the compensatory increase in renin levels following the inhibition of the renin-angiotensin system by AT1R antagonists. Therefore, a combination of AT1R antagonists and vitamin D may offer protection against COVID-19 induced lung injury. |Angiotensin II Type 1 Receptor Blockers/pharmacology/*therapeutic use[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/blood/complications/*drug therapy[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/blood[MESH] |Pneumonia, Viral/blood/complications/*drug therapy[MESH] |Renin-Angiotensin System/drug effects[MESH] |SARS-CoV-2[MESH] |Severe Acute Respiratory Syndrome/*drug therapy/virology[MESH] |Virus Internalization[MESH] |Vitamin D/pharmacology/*therapeutic use[MESH]Can a Combination of AT1R Antagonist and Vitamin D Treat the Lung Comp(epmc).pdf DeepDyve Pubget Overpricing