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10.1016/j.ebiom.2020.102887 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2020.102887 32736307!7387269!32736307     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32736307&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EBioMedicine 2020 ; 58 (ä): 102887 Nephropedia Template TP {{tp|p=32736307|t=2020. The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19) |pdf=|usr=}}{{32736307}} gab.com Text The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19) JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=32736307 #FOAvip The pathogenesis of coronavirus disease 2019 (COVID-19) may be envisaged as the dynamic interaction between four vicious feedback loops chained or happening at once. These are the viral loop, the hyperinflammatory loop, the non-canonical renin-angiotensin system (RAS) axis loop, and the hypercoagulation loop. Severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 lights the wick by infecting alveolar epithelial cells (AECs) and downregulating the angiotensin converting enzyme-2 (ACE2)/angiotensin (Ang-1-7)/Mas1R axis. The viral feedback loop includes evading the host's innate response, uncontrolled viral replication, and turning on a hyperactive adaptative immune response. The inflammatory loop is composed of the exuberant inflammatory response feeding back until exploding in an actual cytokine storm. Downregulation of the ACE2/Ang-(1-7)/Mas1R axis leaves the lung without a critical defense mechanism and turns the scale to the inflammatory side of the RAS. The coagulation loop is a hypercoagulable state caused by the interplay between inflammation and coagulation in an endless feedback loop. The result is a hyperinflammatory and hypercoagulable state producing acute immune-mediated lung injury and eventually, adult respiratory distress syndrome. Twit Text FOAVip The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19) ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=32736307 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32736307 #FOAvip English Wikipedia <ref>{{Cite pmid|32736307}}</ref> The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19) #MMPMID32736307 Domingo P; Mur I; Pomar V; Corominas H; Casademont J; de Benito N EBioMedicine 2020[Aug]; 58 (ä): 102887 PMID32736307show ga The pathogenesis of coronavirus disease 2019 (COVID-19) may be envisaged as the dynamic interaction between four vicious feedback loops chained or happening at once. These are the viral loop, the hyperinflammatory loop, the non-canonical renin-angiotensin system (RAS) axis loop, and the hypercoagulation loop. Severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 lights the wick by infecting alveolar epithelial cells (AECs) and downregulating the angiotensin converting enzyme-2 (ACE2)/angiotensin (Ang-1-7)/Mas1R axis. The viral feedback loop includes evading the host's innate response, uncontrolled viral replication, and turning on a hyperactive adaptative immune response. The inflammatory loop is composed of the exuberant inflammatory response feeding back until exploding in an actual cytokine storm. Downregulation of the ACE2/Ang-(1-7)/Mas1R axis leaves the lung without a critical defense mechanism and turns the scale to the inflammatory side of the RAS. The coagulation loop is a hypercoagulable state caused by the interplay between inflammation and coagulation in an endless feedback loop. The result is a hyperinflammatory and hypercoagulable state producing acute immune-mediated lung injury and eventually, adult respiratory distress syndrome. |*Blood Coagulation[MESH] |*Renin-Angiotensin System[MESH] |Animals[MESH] |Betacoronavirus/*pathogenicity[MESH] |COVID-19[MESH] |Coronavirus Infections/*etiology/metabolism/pathology/virology[MESH] |Cytokines/*metabolism[MESH] |Feedback, Physiological[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*etiology/metabolism/pathology/virology[MESH]The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-(epmc).pdf DeepDyve Pubget Overpricing