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10.1016/j.biopha.2020.110529

http://scihub22266oqcxt.onion/10.1016/j.biopha.2020.110529
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suck abstract from ncbi


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pmid32736237      Biomed+Pharmacother 2020 ; 130 (ä): 110529
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  • Clinical efficacy of glucocorticoid on the treatment of patients with COVID-19 pneumonia: A single-center experience #MMPMID32736237
  • Hu Y; Wang T; Hu Z; Wang X; Zhang Z; Li L; Peng P
  • Biomed Pharmacother 2020[Oct]; 130 (ä): 110529 PMID32736237show ga
  • The aim of the present study was to identify the clinical efficacy of glucocorticoid therapy on the treatment of patients with Coronavirus Disease 2019 (COVID-19) pneumonia. Clinical and laboratory parameters were collected from 308 patients with COVID-19 pneumonia from the fever clinic of Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between January 14, 2020 and February 9, 2020, of which 216 patients received low-dose (equivalent of methylprednisolone 0.75-1.5?mg/kg/d) glucocorticoid treatment. The effect of glucocorticoid on imaging progress, adverse events, nucleic acid results and the outcomes were investigated. Lymphocyte count and C-reactive protein (CRP) significantly differed between the glucocorticoid therapy and non-glucocorticoid therapy groups. Compared with the non-glucocorticoid therapy group, glucocorticoid therapy did not significantly influence the clinical course of COVID-19 pneumonia, including imaging progress and the time duration for negative transformation of nucleic acid. Glucocorticoid therapy did not significantly influence the outcomes nor the adverse events of COVID-19 pneumonia. For the treatment of COVID-19 pneumonia, systemic and in-depth investigation is needed to determine the timing and dosage of glucocorticoids needed to inhibit overwhelming inflammatory response and not the protective immune response to COVID-19 pneumonia.
  • |*Betacoronavirus/isolation & purification[MESH]
  • |*Pandemics[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coinfection/etiology[MESH]
  • |Coronavirus Infections/diagnosis/diagnostic imaging/*drug therapy[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Methylprednisolone/adverse effects/*therapeutic use[MESH]
  • |Middle Aged[MESH]
  • |Pharynx/virology[MESH]
  • |Pneumonia, Viral/diagnosis/diagnostic imaging/*drug therapy[MESH]
  • |Prednisolone/adverse effects/*therapeutic use[MESH]
  • |RNA, Viral/analysis[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Tomography, X-Ray Computed[MESH]
  • |Treatment Outcome[MESH]


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